HCSGD entry for STON1
1. General information
| Official gene symbol | STON1 |
|---|---|
| Entrez ID | 11037 |
| Gene full name | stonin 1 |
| Other gene symbols | SALF SBLF STN1 STNB1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0006897 | Endocytosis | IEA | biological_process |
| GO:0016192 | Vesicle-mediated transport | IEA | biological_process |
| GO:0030100 | Regulation of endocytosis | IDA | biological_process |
| GO:0030131 | Clathrin adaptor complex | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9529380989 | 0.0037106037 | 0.9999902473 | 0.1236288608 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -1.2912469620 |
| GSE13712_SHEAR | Down | -0.6589550891 |
| GSE13712_STATIC | Down | -1.0323227313 |
| GSE19018 | Up | 0.4334546052 |
| GSE19899_A1 | Down | -0.1388829223 |
| GSE19899_A2 | Down | -2.4347809465 |
| PubMed_21979375_A1 | Down | -1.7619746827 |
| PubMed_21979375_A2 | Down | -1.6889614475 |
| GSE35957 | Down | -0.1794778445 |
| GSE36640 | Down | -0.0260185848 |
| GSE54402 | Down | -0.4762978460 |
| GSE9593 | Up | 0.4167561277 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0548443105 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25684230 | Stn1 is critical for telomere maintenance and long-term viability of somatic human cells |
| 25684230 | The budding yeast CST complex, comprising Cdc13, Stn1, and Ctc1, is critical for telomere replication, length regulation, and end protection |
| 25684230 | Here, we characterize the function of human Stn1 in cultured human fibroblasts and demonstrate its critical role in telomere replication, length regulation, and function |
| 25684230 | In the absence of high telomerase activity, shRNA-mediated knockdown of hStn1 resulted in aberrant and fragile telomeric structures, stochastic telomere attrition, increased telomere erosion rates, telomere dysfunction, and consequently accelerated entry into cellular senescence |
| 25684230 | Oxidative stress augmented the defects caused by Stn1 knockdown leading to almost immediate cessation of cell proliferation |
| 25684230 | In contrast, overexpression of hTERT suppressed some of the defects caused by hStn1 knockdown suggesting that telomerase can partially compensate for hStn1 loss |
| 25684230 | Our findings reveal a critical role for human Stn1 in telomere length maintenance and function, supporting the model that efficient replication of telomeric repeats is critical for long-term viability of normal somatic mammalian cells |
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