HCSGD entry for WWP2

1. General information

Official gene symbolWWP2
Entrez ID11060
Gene full nameWW domain containing E3 ubiquitin protein ligase 2
Other gene symbolsAIP2 WWp2-like
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMP ISSbiological_process
GO:0000151Ubiquitin ligase complexTAScellular_component
GO:0001085RNA polymerase II transcription factor bindingIEA IPI ISSmolecular_function
GO:0004842Ubiquitin-protein ligase activityIDA IEA IMPmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIBA IEA ISScellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0010629Negative regulation of gene expressionIMPbiological_process
GO:0016567Protein ubiquitinationIDAbiological_process
GO:0032410Negative regulation of transporter activityIDAbiological_process
GO:0034765Regulation of ion transmembrane transportIDAbiological_process
GO:0042391Regulation of membrane potentialIDAbiological_process
GO:0042787Protein ubiquitination involved in ubiquitin-dependent protein catabolic processIBAbiological_process
GO:0043161Proteasome-mediated ubiquitin-dependent protein catabolic processIEA IMPbiological_process
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIEA ISSbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedISSbiological_process
GO:0046718Viral entry into host cellTASbiological_process
GO:0051224Negative regulation of protein transportIMPbiological_process
GO:0070534Protein K63-linked ubiquitinationIEA ISSbiological_process
GO:1901016Regulation of potassium ion transmembrane transporter activityIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.27308799820.89730144750.97020709371.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0079088390
GSE13712_SHEARDown-0.1227209791
GSE13712_STATICUp0.1700483187
GSE19018Down-0.0273670271
GSE19899_A1Up0.0693525972
GSE19899_A2Up0.3136296526
PubMed_21979375_A1Up0.2838594155
PubMed_21979375_A2Up0.4134931702
GSE35957Up0.1506122973
GSE36640Down-0.2093721428
GSE54402Down-0.2155939201
GSE9593Up0.0333395395
GSE43922Up0.0447347700
GSE24585Down-0.1122523285
GSE37065Down-0.1834836822
GSE28863_A1Up0.4151798567
GSE28863_A2Up0.2369259861
GSE28863_A3Up0.2011468014
GSE28863_A4Down-0.0047281780
GSE48662Up0.2950152968

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT040274CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046361CLASHFunctional MTI (Weak)23622248
hsa-miR-26a-5pMIMAT0000082MIRT050195CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052448CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.