HCSGD entry for WDR5
1. General information
| Official gene symbol | WDR5 |
|---|---|
| Entrez ID | 11091 |
| Gene full name | WD repeat domain 5 |
| Other gene symbols | BIG-3 SWD3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000123 | Histone acetyltransferase complex | IDA | cellular_component |
| GO:0001501 | Skeletal system development | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0018022 | Peptidyl-lysine methylation | IDA | biological_process |
| GO:0035097 | Histone methyltransferase complex | IDA | cellular_component |
| GO:0042800 | Histone methyltransferase activity (H3-K4 specific) | IDA | molecular_function |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0043981 | Histone H4-K5 acetylation | IDA | biological_process |
| GO:0043982 | Histone H4-K8 acetylation | IDA | biological_process |
| GO:0043984 | Histone H4-K16 acetylation | IDA | biological_process |
| GO:0043995 | Histone acetyltransferase activity (H4-K5 specific) | IDA | molecular_function |
| GO:0043996 | Histone acetyltransferase activity (H4-K8 specific) | IDA | molecular_function |
| GO:0046972 | Histone acetyltransferase activity (H4-K16 specific) | IDA | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0051568 | Histone H3-K4 methylation | IDA | biological_process |
| GO:0071339 | MLL1 complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8552484898 | 0.2455634588 | 0.9999902473 | 0.9537370223 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0701642947 |
| GSE13712_SHEAR | Up | 0.2497589261 |
| GSE13712_STATIC | Up | 0.2689124569 |
| GSE19018 | Down | -0.2780340901 |
| GSE19899_A1 | Down | -0.1732860477 |
| GSE19899_A2 | Up | 0.2372716988 |
| PubMed_21979375_A1 | Up | 0.1273181332 |
| PubMed_21979375_A2 | Down | -0.0444506470 |
| GSE35957 | Down | -0.4385537913 |
| GSE36640 | Down | -1.0649407412 |
| GSE54402 | Up | 0.0862939822 |
| GSE9593 | Down | -0.2721032662 |
| GSE43922 | Up | 0.1062820964 |
| GSE24585 | Down | -0.0512876956 |
| GSE37065 | Down | -0.1941184764 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Down | -0.0347600508 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT039870 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042008 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30c-5p | MIMAT0000244 | MIRT047941 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
