HCSGD entry for CHI3L1

1. General information

Official gene symbolCHI3L1
Entrez ID1116
Gene full namechitinase 3-like 1 (cartilage glycoprotein-39)
Other gene symbolsASRT7 CGP-39 GP-39 GP39 HC-gp39 HCGP-3P YKL-40 YKL40 YYL-40 hCGP-39
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004553Hydrolase activity, hydrolyzing O-glycosyl compoundsIEAmolecular_function
GO:0004568Chitinase activityIDAmolecular_function
GO:0005201Extracellular matrix structural constituentNASmolecular_function
GO:0005578Proteinaceous extracellular matrixNAScellular_component
GO:0005615Extracellular spaceIDA IEAcellular_component
GO:0005737CytoplasmISScellular_component
GO:0005783Endoplasmic reticulumISScellular_component
GO:0005975Carbohydrate metabolic processIEAbiological_process
GO:0006032Chitin catabolic processIEAbiological_process
GO:0006954Inflammatory responseIEPbiological_process
GO:0007250Activation of NF-kappaB-inducing kinase activityISSbiological_process
GO:0008061Chitin bindingIDA IEAmolecular_function
GO:0009612Response to mechanical stimulusIEPbiological_process
GO:0010800Positive regulation of peptidyl-threonine phosphorylationISSbiological_process
GO:0030324Lung developmentIMPbiological_process
GO:0034612Response to tumor necrosis factorIEPbiological_process
GO:0045766Positive regulation of angiogenesisIEA IMPbiological_process
GO:0051216Cartilage developmentNASbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0070555Response to interleukin-1IEPbiological_process
GO:0070741Response to interleukin-6IEPbiological_process
GO:0071356Cellular response to tumor necrosis factorISSbiological_process
GO:0072606Interleukin-8 secretionISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00199702900.92986155160.12028329521.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3583757335
GSE13712_SHEARDown-0.0682185997
GSE13712_STATICDown-0.0810330400
GSE19018Down-0.1647517002
GSE19899_A1Up0.1820170979
GSE19899_A2Up0.9934446374
PubMed_21979375_A1Up0.7775359589
PubMed_21979375_A2Up0.8245314466
GSE35957Down-0.0022834589
GSE36640Down-0.0740950665
GSE54402Down-0.1340225922
GSE9593Up1.2461040104
GSE43922Up1.3046347312
GSE24585Down-0.0714769175
GSE37065Up0.0863014152
GSE28863_A1Up1.6419869728
GSE28863_A2Up1.1302823951
GSE28863_A3Up0.4149728673
GSE28863_A4Up0.0267529611
GSE48662Down-0.0623557175

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.