HCSGD entry for IRAK3

1. General information

Official gene symbolIRAK3
Entrez ID11213
Gene full nameinterleukin-1 receptor-associated kinase 3
Other gene symbolsASRT5 IRAKM
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000287Magnesium ion bindingIDAmolecular_function
GO:0001960Negative regulation of cytokine-mediated signaling pathwayICbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0009615Response to virusICbiological_process
GO:0010933Positive regulation of macrophage tolerance inductionISSbiological_process
GO:0010936Negative regulation of macrophage cytokine productionISSbiological_process
GO:0019221Cytokine-mediated signaling pathwayISSbiological_process
GO:0032088Negative regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0032494Response to peptidoglycanISSbiological_process
GO:0032496Response to lipopolysaccharideISSbiological_process
GO:0032695Negative regulation of interleukin-12 productionIMP ISSbiological_process
GO:0032715Negative regulation of interleukin-6 productionIMP ISSbiological_process
GO:0032720Negative regulation of tumor necrosis factor productionIMPbiological_process
GO:0034122Negative regulation of toll-like receptor signaling pathwayISSbiological_process
GO:0042177Negative regulation of protein catabolic processIMPbiological_process
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043242Negative regulation of protein complex disassemblyIMPbiological_process
GO:0043244Regulation of protein complex disassemblyISSbiological_process
GO:0043330Response to exogenous dsRNAISSbiological_process
GO:0043407Negative regulation of MAP kinase activityIMPbiological_process
GO:0045824Negative regulation of innate immune responseISSbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0051092Positive regulation of NF-kappaB transcription factor activityIMPbiological_process
GO:0070498Interleukin-1-mediated signaling pathwayIMPbiological_process
GO:0070555Response to interleukin-1IMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00789178980.93529105280.22977853981.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1619956162
GSE13712_SHEARDown-0.1898179421
GSE13712_STATICDown-0.0231148634
GSE19018Up0.0048084819
GSE19899_A1Up0.1634478021
GSE19899_A2Up0.7498576720
PubMed_21979375_A1Up1.1194429302
PubMed_21979375_A2Up0.2469178105
GSE35957Up0.0399536567
GSE36640Down-0.7361179194
GSE54402Up0.6692078634
GSE9593Down-0.4690494136
GSE43922Up0.3600600486
GSE24585Up0.4080377921
GSE37065Up0.9796919939
GSE28863_A1Up1.1517230600
GSE28863_A2Up0.5629525207
GSE28863_A3Down-0.0974256550
GSE28863_A4Up0.5038664467
GSE48662Down-0.2674560014

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-155-3pMIMAT0004658MIRT005808Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20852130
hsa-miR-124-3pMIMAT0000422MIRT023129MicroarrayFunctional MTI (Weak)18668037
hsa-miR-16-5pMIMAT0000069MIRT051159CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23634235Amongst the genes were IRAK3, SelS, HSPA5, HERPUD1, DNAJB9, SEPR1, C18orf55, ARF4, RINT1, NXT1, CADPS2, COG6, and GLRX5
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