HCSGD entry for DUSP10
1. General information
| Official gene symbol | DUSP10 |
|---|---|
| Entrez ID | 11221 |
| Gene full name | dual specificity phosphatase 10 |
| Other gene symbols | MKP-5 MKP5 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000188 | Inactivation of MAPK activity | IBA IDA | biological_process |
| GO:0002819 | Regulation of adaptive immune response | IEA | biological_process |
| GO:0004721 | Phosphoprotein phosphatase activity | TAS | molecular_function |
| GO:0004725 | Protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0006470 | Protein dephosphorylation | IBA IDA | biological_process |
| GO:0006950 | Response to stress | TAS | biological_process |
| GO:0007254 | JNK cascade | TAS | biological_process |
| GO:0016791 | Phosphatase activity | IDA | molecular_function |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | IBA | molecular_function |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0032873 | Negative regulation of stress-activated MAPK cascade | IBA | biological_process |
| GO:0033549 | MAP kinase phosphatase activity | IDA | molecular_function |
| GO:0043508 | Negative regulation of JUN kinase activity | IBA | biological_process |
| GO:0046329 | Negative regulation of JNK cascade | IBA | biological_process |
| GO:0060266 | Negative regulation of respiratory burst involved in inflammatory response | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2592460583 | 0.0263835797 | 0.9527527925 | 0.3113258961 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1862195838 |
| GSE13712_SHEAR | Down | -0.2005564500 |
| GSE13712_STATIC | Up | 0.0767371662 |
| GSE19018 | Up | 0.6806198564 |
| GSE19899_A1 | Down | -0.7069064448 |
| GSE19899_A2 | Down | -0.5308819963 |
| PubMed_21979375_A1 | Down | -0.5974738817 |
| PubMed_21979375_A2 | Down | -0.4969163418 |
| GSE35957 | Down | -0.6472368859 |
| GSE36640 | Up | 0.9343676651 |
| GSE54402 | Down | -0.1639479698 |
| GSE9593 | Up | 1.1519632504 |
| GSE43922 | Down | -1.2586405875 |
| GSE24585 | Down | -0.0181033847 |
| GSE37065 | Up | 0.2586075775 |
| GSE28863_A1 | Down | -0.1288244124 |
| GSE28863_A2 | Up | 0.2990735871 |
| GSE28863_A3 | Down | -0.3708950767 |
| GSE28863_A4 | Down | -0.2493774740 |
| GSE48662 | Down | -0.1565706417 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-21-5p | MIMAT0000076 | MIRT006323 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22387553 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027621 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
