HCSGD entry for CHRM1

1. General information

Official gene symbolCHRM1
Entrez ID1128
Gene full namecholinergic receptor, muscarinic 1
Other gene symbolsHM1 M1 M1R
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004435Phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006464Cellular protein modification processTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007207Phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayTASbiological_process
GO:0007213G-protein coupled acetylcholine receptor signaling pathwayTASbiological_process
GO:0007274Neuromuscular synaptic transmissionIEAbiological_process
GO:0007399Nervous system developmentTASbiological_process
GO:0008144Drug bindingIEAmolecular_function
GO:0008283Cell proliferationTASbiological_process
GO:0008284Positive regulation of cell proliferationTASbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016020MembraneTAScellular_component
GO:0016907G-protein coupled acetylcholine receptor activityIEAmolecular_function
GO:0030054Cell junctionIEAcellular_component
GO:0030425DendriteIEAcellular_component
GO:0032279Asymmetric synapseIEAcellular_component
GO:0040012Regulation of locomotionIEAbiological_process
GO:0043270Positive regulation of ion transportIGIbiological_process
GO:0043679Axon terminusIEAcellular_component
GO:0045211Postsynaptic membraneIEAcellular_component
GO:0046541Saliva secretionIEAbiological_process
GO:0050890CognitionIEAbiological_process
GO:0090316Positive regulation of intracellular protein transportIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53805673800.84184273390.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0599330638
GSE13712_SHEARDown-0.2634269350
GSE13712_STATICDown-0.0822618272
GSE19018Up0.1864266036
GSE19899_A1Down-0.0034792962
GSE19899_A2Up0.1176108828
PubMed_21979375_A1Down-0.3669331635
PubMed_21979375_A2Up0.0328889504
GSE35957Up0.2922714704
GSE36640Up0.1127109516
GSE54402Down-0.0354422538
GSE9593Down-0.0012978681
GSE43922Up0.0651534517
GSE24585Up0.0365033928
GSE37065Up0.0087590477
GSE28863_A1Up0.0194346102
GSE28863_A2Up0.0697222906
GSE28863_A3Up0.2136706928
GSE28863_A4Up0.0706286082
GSE48662Up0.1199187950

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-107MIMAT0000104MIRT007151Luciferase reporter assayFunctional MTI23423139
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

20214903This work studied the role of cyclic AMP responsive element binding protein (CREB) in the up-regulation of M(1) muscarinic acetylcholine receptor (M(1) receptor) density by sarsasapogenin (ZMS) in CHO cells transfected with M(1) receptor gene (CHOm1 cells)
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