HCSGD entry for MED8
1. General information
| Official gene symbol | MED8 |
|---|---|
| Entrez ID | 112950 |
| Gene full name | mediator complex subunit 8 |
| Other gene symbols | ARC32 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001104 | RNA polymerase II transcription cofactor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016567 | Protein ubiquitination | IEA | biological_process |
| GO:0016592 | Mediator complex | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9775129060 | 0.1619991338 | 0.9999902473 | 0.7774754786 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0552224825 |
| GSE13712_SHEAR | Down | -0.0598618956 |
| GSE13712_STATIC | Up | 0.1558954903 |
| GSE19018 | Down | -0.1540687206 |
| GSE19899_A1 | Up | 0.0355548102 |
| GSE19899_A2 | Down | -0.1391059395 |
| PubMed_21979375_A1 | Up | 0.1941025339 |
| PubMed_21979375_A2 | Down | -0.3906729775 |
| GSE35957 | Down | -0.3963806687 |
| GSE36640 | Up | 0.0952041135 |
| GSE54402 | Down | -0.0639264615 |
| GSE9593 | Down | -0.1057152597 |
| GSE43922 | Up | 0.0237722729 |
| GSE24585 | Up | 0.0140897340 |
| GSE37065 | Down | -0.1809656431 |
| GSE28863_A1 | Down | -0.0591203905 |
| GSE28863_A2 | Down | -0.1753890193 |
| GSE28863_A3 | Down | -0.3920375924 |
| GSE28863_A4 | Down | -0.2055747607 |
| GSE48662 | Down | -0.2157494798 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019689 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027422 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040043 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045059 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
