HCSGD entry for TOP1MT
1. General information
| Official gene symbol | TOP1MT |
|---|---|
| Entrez ID | 116447 |
| Gene full name | topoisomerase (DNA) I, mitochondrial |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003917 | DNA topoisomerase type I activity | IBA IEA | molecular_function |
| GO:0003918 | DNA topoisomerase type II (ATP-hydrolyzing) activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005694 | Chromosome | IEA | cellular_component |
| GO:0005730 | Nucleolus | IBA | cellular_component |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0006260 | DNA replication | IBA | biological_process |
| GO:0006265 | DNA topological change | IBA IEA | biological_process |
| GO:0006338 | Chromatin remodeling | IBA | biological_process |
| GO:0007059 | Chromosome segregation | IBA | biological_process |
| GO:0031298 | Replication fork protection complex | IBA | cellular_component |
| GO:0042645 | Mitochondrial nucleoid | IDA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3909095513 | 0.6565096007 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0964309861 |
| GSE13712_SHEAR | Down | -0.0709259308 |
| GSE13712_STATIC | Down | -0.1134458455 |
| GSE19018 | Down | -0.0439438059 |
| GSE19899_A1 | Up | 0.0604093308 |
| GSE19899_A2 | Up | 0.3252032136 |
| PubMed_21979375_A1 | Up | 0.2205439691 |
| PubMed_21979375_A2 | Up | 0.1832418338 |
| GSE35957 | Down | -0.1360216300 |
| GSE36640 | Down | -0.2813397607 |
| GSE54402 | Up | 0.0181063282 |
| GSE9593 | Down | -0.0098111156 |
| GSE43922 | Up | 0.1341266822 |
| GSE24585 | Down | -0.4024115258 |
| GSE37065 | Down | -0.2154125291 |
| GSE28863_A1 | Down | -0.1509971318 |
| GSE28863_A2 | Up | 0.0550233658 |
| GSE28863_A3 | Up | 0.5150043546 |
| GSE28863_A4 | Up | 0.1940912385 |
| GSE48662 | Up | 0.0644477767 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
