HCSGD entry for CMA1

1. General information

Official gene symbolCMA1
Entrez ID1215
Gene full namechymase 1, mast cell
Other gene symbolsCYH MCT1 chymase
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002003Angiotensin maturationTASbiological_process
GO:0004252Serine-type endopeptidase activityIDA IEA NASmolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005622IntracellularIEAcellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0006518Peptide metabolic processIEAbiological_process
GO:0008236Serine-type peptidase activityTASmolecular_function
GO:0022617Extracellular matrix disassemblyTASbiological_process
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030901Midbrain developmentIEAbiological_process
GO:0031012Extracellular matrixIDAcellular_component
GO:0042277Peptide bindingIEAmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0045766Positive regulation of angiogenesisIEAbiological_process
GO:0050720Interleukin-1 beta biosynthetic processIDAbiological_process
GO:0050727Regulation of inflammatory responseICbiological_process
GO:0071333Cellular response to glucose stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.52198427490.69224145360.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0626029427
GSE13712_SHEARUp0.2066217108
GSE13712_STATICUp0.2492690846
GSE19018Up0.2054797196
GSE19899_A1Up0.0341520886
GSE19899_A2Down-0.0646023987
PubMed_21979375_A1Down-0.3658514226
PubMed_21979375_A2Down-0.2480874992
GSE35957Up0.0099056117
GSE36640Up0.2459112615
GSE54402Down-0.2168120090
GSE9593Up0.1010898305
GSE43922Up0.0100817171
GSE24585Up0.0232105223
GSE37065Up0.0144810146
GSE28863_A1Up0.0487342342
GSE28863_A2Down-0.0956966316
GSE28863_A3Up0.3161140915
GSE28863_A4Down-0.0406545704
GSE48662Up0.2824805847

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PhenylalanylmethaneDB03149 EXPT02591
Benzylsulfinic AcidDB03297 EXPT02622
2-(N-Morpholino)-Ethanesulfonic AcidDB03814 EXPT02154
2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic AcidDB04016 EXPT02424
[(1S)-1-(5-CHLORO-1-BENZOTHIEN-3-YL)-2-(2-NAPHTHYLAMINO)-2-OXOETHYL]PHOSPHONIC ACIDDB07680 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16436134On the other hand, the expression level of chymase (CMAI) doubled every 4-6 weeks
16436134After filtering the transcripts with MC-specificity, hierarchical clustering analysis identified 494 and 81 transcripts in the same clusters with tryptase and chymase, respectively
16436134In the chymase cluster, a critical suppressor for cell senescence, BMI1 and the several related genes were found, suggesting that chymase expression may be closely related to cell senescence/quiescence events
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