HCSGD entry for FGD4

1. General information

Official gene symbolFGD4
Entrez ID121512
Gene full nameFYVE, RhoGEF and PH domain containing 4
Other gene symbolsCMT4H FRABP ZFYVE6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleISScellular_component
GO:0003779Actin bindingIEAmolecular_function
GO:0005085Guanyl-nucleotide exchange factor activityISSmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005737CytoplasmISScellular_component
GO:0005794Golgi apparatusISScellular_component
GO:0005829CytosolTAScellular_component
GO:0007010Cytoskeleton organizationISSbiological_process
GO:0007264Small GTPase mediated signal transductionTASbiological_process
GO:0008360Regulation of cell shapeISSbiological_process
GO:0015629Actin cytoskeletonIDAcellular_component
GO:0030027LamellipodiumIEA ISScellular_component
GO:0030032Lamellipodium assemblyIEAbiological_process
GO:0030035Microspike assemblyIEAbiological_process
GO:0030036Actin cytoskeleton organizationISSbiological_process
GO:0030175FilopodiumIEAcellular_component
GO:0031267Small GTPase bindingISSmolecular_function
GO:0043065Positive regulation of apoptotic processTASbiological_process
GO:0043088Regulation of Cdc42 GTPase activityISSbiological_process
GO:0046847Filopodium assemblyISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0051056Regulation of small GTPase mediated signal transductionTASbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.04442195590.00878199540.46938134780.1864568090

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0425302582
GSE13712_SHEARUp0.7178760062
GSE13712_STATICUp0.1155789224
GSE19018Down-0.6762344576
GSE19899_A1Down-1.6068140398
GSE19899_A2Down-0.1862670529
PubMed_21979375_A1Down-3.2114985735
PubMed_21979375_A2Down-0.5783560364
GSE35957Up1.2656687523
GSE36640Down-0.3657621745
GSE54402Down-3.1168227941
GSE9593Up1.3832427174
GSE43922Down-0.8630518219
GSE24585Up0.3332076371
GSE37065Up0.7436798673
GSE28863_A1Down-0.0332599031
GSE28863_A2Up0.3716544337
GSE28863_A3Up0.1403091708
GSE28863_A4Up0.2844479464
GSE48662Up0.0743464960

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.