HCSGD entry for CCR1

1. General information

Official gene symbolCCR1
Entrez ID1230
Gene full namechemokine (C-C motif) receptor 1
Other gene symbolsCD191 CKR-1 CKR1 CMKBR1 HM145 MIP1aR SCYAR1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002407Dendritic cell chemotaxisTASbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0004950Chemokine receptor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneIDA IMP TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006816Calcium ion transportIDAbiological_process
GO:0006874Cellular calcium ion homeostasisIDAbiological_process
GO:0006887ExocytosisIDAbiological_process
GO:0006935ChemotaxisNASbiological_process
GO:0006954Inflammatory responseIEAbiological_process
GO:0006955Immune responseIDAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDAbiological_process
GO:0007267Cell-cell signalingIDAbiological_process
GO:0008152Metabolic processIDAbiological_process
GO:0009611Response to woundingTASbiological_process
GO:0009897External side of plasma membraneIDAcellular_component
GO:0010629Negative regulation of gene expressionIMPbiological_process
GO:0016493C-C chemokine receptor activityIDAmolecular_function
GO:0019221Cytokine-mediated signaling pathwayNASbiological_process
GO:0019957C-C chemokine bindingIPImolecular_function
GO:0030502Negative regulation of bone mineralizationIMPbiological_process
GO:0035717Chemokine (C-C motif) ligand 7 bindingIPImolecular_function
GO:0045672Positive regulation of osteoclast differentiationIMPbiological_process
GO:0051928Positive regulation of calcium ion transportIDAbiological_process
GO:0070098Chemokine-mediated signaling pathwayIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0071791Chemokine (C-C motif) ligand 5 bindingIPImolecular_function
GO:0090026Positive regulation of monocyte chemotaxisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00660665630.98207452600.21415073711.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0336090897
GSE13712_SHEARUp0.0057979237
GSE13712_STATICUp0.1249930159
GSE19018Down-0.0153163313
GSE19899_A1Up0.3655810807
GSE19899_A2Up1.0388723377
PubMed_21979375_A1Up1.1936862407
PubMed_21979375_A2Up0.9389656101
GSE35957Up0.0581137150
GSE36640Up0.2327550952
GSE54402Up1.1457401011
GSE9593Up0.5453416061
GSE43922Up1.0399892806
GSE24585Down-0.1435307919
GSE37065Up0.9724804839
GSE28863_A1Up0.0110870729
GSE28863_A2Up0.0116933545
GSE28863_A3Up0.1746084899
GSE28863_A4Up0.1563345686
GSE48662Down-0.0288658810

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT005956Luciferase reporter assayNon-Functional MTI21131358
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.