HCSGD entry for PLK3

1. General information

Official gene symbolPLK3
Entrez ID1263
Gene full namepolo-like kinase 3
Other gene symbolsCNK FNK PRK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000075Cell cycle checkpointISSbiological_process
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0000084Mitotic S phaseIMPbiological_process
GO:0000086G2/M transition of mitotic cell cycleTASbiological_process
GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000302Response to reactive oxygen speciesIDAbiological_process
GO:0000910CytokinesisTASbiological_process
GO:0002039P53 bindingIDAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005795Golgi stackIDAcellular_component
GO:0005813CentrosomeIDAcellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006970Response to osmotic stressIDAbiological_process
GO:0006974Cellular response to DNA damage stimulusIDA IMPbiological_process
GO:0007093Mitotic cell cycle checkpointTASbiological_process
GO:0007113Endomitotic cell cycleTASbiological_process
GO:0009314Response to radiationIDAbiological_process
GO:0030425DendriteIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043491Protein kinase B signalingISSbiological_process
GO:0090166Golgi disassemblyIDAbiological_process
GO:2000777Positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxiaIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00317342810.98817303670.15182481881.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0051380624
GSE13712_SHEARUp0.4002193495
GSE13712_STATICUp0.1242923238
GSE19018Down-0.0140799601
GSE19899_A1Up0.6143989262
GSE19899_A2Up1.2825029130
PubMed_21979375_A1Up0.8271522542
PubMed_21979375_A2Up1.2191885257
GSE35957Up0.1781490357
GSE36640Up0.5889730767
GSE54402Up0.4123403457
GSE9593Up0.0394587883
GSE43922Up1.6246514948
GSE24585Up1.1010550723
GSE37065Up0.2170069103
GSE28863_A1Up0.1298982103
GSE28863_A2Down-0.0568900480
GSE28863_A3Down-0.0387475161
GSE28863_A4Down-0.2310340447
GSE48662Up0.7422916196

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT017129MicroarrayFunctional MTI (Weak)18185580
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16678508Long-term corneal keratocyte deficits after PRK and LASIK: in vivo evidence of stress-induced premature cellular senescence
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