HCSGD entry for CORT
1. General information
| Official gene symbol | CORT |
|---|---|
| Entrez ID | 1325 |
| Gene full name | cortistatin |
| Other gene symbols | CST-14 CST-17 CST-29 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001664 | G-protein coupled receptor binding | IPI | molecular_function |
| GO:0005184 | Neuropeptide hormone activity | IDA | molecular_function |
| GO:0005615 | Extracellular space | NAS | cellular_component |
| GO:0007193 | Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0007268 | Synaptic transmission | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9619644998 | 0.1368929030 | 0.9999902473 | 0.7129300099 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1319154262 |
| GSE13712_SHEAR | Down | -0.2117438507 |
| GSE13712_STATIC | Down | -0.1412968195 |
| GSE19018 | Up | 0.2364643950 |
| GSE19899_A1 | Up | 0.0142385932 |
| GSE19899_A2 | Down | -0.3961524820 |
| PubMed_21979375_A1 | Down | -0.4688349666 |
| PubMed_21979375_A2 | Down | -0.2199241966 |
| GSE35957 | Down | -0.1945484112 |
| GSE36640 | Down | -0.4101404977 |
| GSE54402 | Down | -0.0081594433 |
| GSE9593 | Down | -0.0803002230 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.2046631627 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27158328 | These alterations were prevented/inhibited by cortisol (Cort) or canrenone (Can) raising the hypothesis that Aldo effects in RBC may be mediated by mineralocorticoid receptor (MR), though to date MR has never been demonstrated in human RBC |
| 27158328 | Cort induced MR release but not dimers formation while Can was not able to induce MR release |
| 24828412 | Here, we chronically treated pre-laying zebra finch females (Taeniopygia guttata) with 17-beta-estradiol (E2) or CORT, and followed offspring growth and cellular ageing rates (oxidative stress and telomere loss) |
| 24828412 | CORT treatment decreased growth rate in male chicks and increased rate of telomere loss in mothers and female offspring |
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