HCSGD entry for CR1
1. General information
| Official gene symbol | CR1 |
|---|---|
| Entrez ID | 1378 |
| Gene full name | complement component (3b/4b) receptor 1 (Knops blood group) |
| Other gene symbols | C3BR C4BR CD35 KN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001851 | Complement component C3b binding | IDA | molecular_function |
| GO:0001855 | Complement component C4b binding | IDA | molecular_function |
| GO:0001861 | Complement component C4b receptor activity | IDA | molecular_function |
| GO:0002430 | Complement receptor mediated signaling pathway | IDA | biological_process |
| GO:0004877 | Complement component C3b receptor activity | IDA | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | IDA | cellular_component |
| GO:0006958 | Complement activation, classical pathway | IEA | biological_process |
| GO:0007165 | Signal transduction | IDA | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0030449 | Regulation of complement activation | TAS | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045957 | Negative regulation of complement activation, alternative pathway | IDA | biological_process |
| GO:0045959 | Negative regulation of complement activation, classical pathway | IDA | biological_process |
| GO:1900004 | Negative regulation of serine-type endopeptidase activity | IDA | biological_process |
| GO:1900005 | Positive regulation of serine-type endopeptidase activity | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6259627674 | 0.9225420729 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0002985529 |
| GSE13712_SHEAR | Up | 0.0105075257 |
| GSE13712_STATIC | Up | 0.0035076647 |
| GSE19018 | Up | 0.1350710826 |
| GSE19899_A1 | Up | 0.0610772924 |
| GSE19899_A2 | Up | 0.0054282918 |
| PubMed_21979375_A1 | Up | 0.0443443727 |
| PubMed_21979375_A2 | Down | -0.0628887935 |
| GSE35957 | Up | 0.1310201299 |
| GSE36640 | Up | 0.1000998410 |
| GSE54402 | Up | 0.0869566103 |
| GSE9593 | Up | 0.0869480930 |
| GSE43922 | Up | 0.0158600504 |
| GSE24585 | Up | 0.3561130450 |
| GSE37065 | Up | 0.0364004306 |
| GSE28863_A1 | Down | -0.0711791426 |
| GSE28863_A2 | Down | -0.0729547754 |
| GSE28863_A3 | Up | 0.0953966839 |
| GSE28863_A4 | Up | 0.0215641897 |
| GSE48662 | Up | 0.0271698164 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-183-5p | MIMAT0000261 | MIRT047066 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 9614933 | Analysis of complement receptor type 1 (CR1) expression on erythrocytes and of CR1 allelic markers in Caucasian and African American populations |
| 9614933 | CR1 expression on erythrocytes (E) is regulated by an element that is tightly linked in Caucasians to the site of an RFLP of the CR1 gene |
| 9614933 | When age-fractionated E of donors heterozygous for both the H and L alleles and for CR1 allotypes of differing molecular weights were analyzed in Western blots, the product of the L allele appeared to have an increased rate of loss during cell aging |
| 9614933 | A coding sequence polymorphism of CR1 predicted to cause a Pro-->Arg substitution in its proximal extramembranous region was tightly linked in Caucasians to the site of the HindIII RFLP |
| 9614933 | However, neither this polymorphism nor the HindIII RFLP correlated with CR1 expression among African Americans |
| 9614933 | Relative instability of CR1 encoded by the L allele thus may derive from another coding sequence polymorphism, or may require both the Pro-->Arg substitution and epistatic effects of another polymorphic gene |
| 1531948 | Peripheral catabolism of CR1 (the C3b receptor, CD35) on erythrocytes from healthy individuals and patients with systemic lupus erythematosus (SLE) |
| 1531948 | The present study investigated the rate of catabolism of CR1 (the C3b receptor, CD35) on erythrocytes (E) in vivo, in relationship with the expressed number of CR1/E, the CR1 |
| 1531948 | 1 HindIII quantitative CR1 polymorphism, and cell age |
| 1531948 | The relationship between the number of CR1/E and cell age was analysed by measuring G6PDH activity in E that had been sorted according to high or low expression of CR1 (CD35), by assessing the expression of CR1 (CD35) on E separated according to cell density, and by comparing the number of CR1 (CD35) antigenic sites on reticulocytes and on E |
| 1531948 | A physiological catabolism of CR1 (CD35) manifested by a reduction in the number of CR1 (CD35) antigenic sites/E with cell ageing was consistently observed in healthy individuals |
| 1531948 | The number of CR1/E decreased with ageing of E according to a complex pattern that associated an exponential decay and an offset |
| 1531948 | Calculated half-lives of CR1 (CD35) ranged between 11 and 32 days in healthy individuals |
| 1531948 | A more rapid loss of CR1 (CD35) with cell ageing occurred on cells from individuals expressing high numbers of CR1/E |
| 1531948 | In patients with systemic lupus erythematosus (SLE), half-lives of CR1 (CD35) on E were in the same range as those of healthy individuals with a similar quantitative CR1 genotype; the number of CR1 (CD35) on reticulocytes was reduced and linearly related to the number of CR1/E, independently of the patients' quantitative CR1 genotype |
| 1531948 | Transfusion experiments with E bearing high or low amounts of CR1/E indicated the lack of preferential removal of E bearing high numbers of CR1 (CD35) in patients with SLE |
| 1531948 | These results indicate that the rate of loss of CR1 (CD35) from E with cell ageing is directly related to the quantitative CR1 phenotype and suggest that enhanced peripheral catabolism is not the sole mechanism of the acquired loss of CR1 (CD35) on E in patients with SLE |
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