HCSGD entry for CREBBP

1. General information

Official gene symbolCREBBP
Entrez ID1387
Gene full nameCREB binding protein
Other gene symbolsCBP KAT3A RSTS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000123Histone acetyltransferase complexIEAcellular_component
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000940Condensed chromosome outer kinetochoreIEAcellular_component
GO:0000987Core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0001102RNA polymerase II activating transcription factor bindingTASmolecular_function
GO:0001105RNA polymerase II transcription coactivator activityTASmolecular_function
GO:0001191RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcriptionIDAmolecular_function
GO:0001666Response to hypoxiaTASbiological_process
GO:0002039P53 bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003712Transcription cofactor activityIEAmolecular_function
GO:0003713Transcription coactivator activityIDA IPImolecular_function
GO:0004402Histone acetyltransferase activityIDA IEAmolecular_function
GO:0004871Signal transducer activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIC IDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006355Regulation of transcription, DNA-templatedIDA IEA TASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006461Protein complex assemblyTASbiological_process
GO:0007165Signal transductionNASbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008589Regulation of smoothened signaling pathwayTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0016407Acetyltransferase activityIDAmolecular_function
GO:0016573Histone acetylationIDAbiological_process
GO:0016604Nuclear bodyIDAcellular_component
GO:0018076N-terminal peptidyl-lysine acetylationIDAbiological_process
GO:0030718Germ-line stem cell maintenanceIEAbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0042592Homeostatic processNASbiological_process
GO:0042733Embryonic digit morphogenesisTASbiological_process
GO:0043426MRF bindingIDAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0061418Regulation of transcription from RNA polymerase II promoter in response to hypoxiaTASbiological_process
GO:0071456Cellular response to hypoxiaTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.20363612320.61623828500.87053863891.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1692118592
GSE13712_SHEARUp0.2284070134
GSE13712_STATICUp0.0674889413
GSE19018Down-0.1300932640
GSE19899_A1Down-0.1634771273
GSE19899_A2Up0.0252329134
PubMed_21979375_A1Down-0.1120208986
PubMed_21979375_A2Down-0.0647793837
GSE35957Up0.0859220535
GSE36640Down-0.2679262625
GSE54402Up0.0135552654
GSE9593Down-0.0088344281
GSE43922Down-0.1115956805
GSE24585Up0.2978358959
GSE37065Down-0.0415616399
GSE28863_A1Up1.2731955748
GSE28863_A2Up0.9801601040
GSE28863_A3Up0.1546495299
GSE28863_A4Down-0.0668180586
GSE48662Up0.1773355609

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Compound

Target

Confidence score

Uniprot

CHEMBL1828983CHEMBL57479Q92793
CHEMBL1828982CHEMBL57479Q92793
CHEMBL1828981CHEMBL57479Q92793
CHEMBL1828980CHEMBL57479Q92793
CHEMBL1828985CHEMBL57479Q92793
CHEMBL1828986CHEMBL57479Q92793
CHEMBL1828984CHEMBL57479Q92793
CHEMBL1828978CHEMBL57479Q92793
CHEMBL549944CHEMBL57478Q92793
CHEMBL540163CHEMBL57478Q92793
CHEMBL505121CHEMBL57477Q92793
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  • Drugs

Name

Drug

Accession number

9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONEDB08655 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-324-3pMIMAT0000762MIRT004683Luciferase reporter assayFunctional MTI19478946
hsa-miR-1301-3pMIMAT0005797MIRT035967CLASHFunctional MTI (Weak)23622248
hsa-miR-935MIMAT0004978MIRT036676CLASHFunctional MTI (Weak)23622248
hsa-miR-769-5pMIMAT0003886MIRT039168CLASHFunctional MTI (Weak)23622248
hsa-miR-125b-5pMIMAT0000423MIRT045961CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048558CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051673CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.