HCSGD entry for PARP4
1. General information
| Official gene symbol | PARP4 |
|---|---|
| Entrez ID | 143 |
| Gene full name | poly (ADP-ribose) polymerase family, member 4 |
| Other gene symbols | ADPRTL1 ARTD4 PARP-4 PARPL PH5P VAULT3 VPARP VWA5C p193 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003950 | NAD+ ADP-ribosyltransferase activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | NAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005876 | Spindle microtubule | IDA | cellular_component |
| GO:0006281 | DNA repair | NAS | biological_process |
| GO:0006464 | Cellular protein modification process | IDA | biological_process |
| GO:0006471 | Protein ADP-ribosylation | NAS | biological_process |
| GO:0006810 | Transport | NAS | biological_process |
| GO:0006954 | Inflammatory response | IMP | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | NAS | biological_process |
| GO:0008219 | Cell death | IMP | biological_process |
| GO:0019899 | Enzyme binding | IDA | molecular_function |
| GO:0030529 | Ribonucleoprotein complex | NAS | cellular_component |
| GO:0042493 | Response to drug | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0124334752 | 0.9367973215 | 0.2789953112 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6294192701 |
| GSE13712_SHEAR | Up | 0.7039341457 |
| GSE13712_STATIC | Up | 0.5813469844 |
| GSE19018 | Down | -0.2564180433 |
| GSE19899_A1 | Up | 0.5951958476 |
| GSE19899_A2 | Up | 0.4010071426 |
| PubMed_21979375_A1 | Up | 0.4041682585 |
| PubMed_21979375_A2 | Up | 1.4097427450 |
| GSE35957 | Down | -1.0379254959 |
| GSE36640 | Up | 0.4344957362 |
| GSE54402 | Up | 0.3780622938 |
| GSE9593 | Up | 0.2439580459 |
| GSE43922 | Up | 0.2063623736 |
| GSE24585 | Up | 0.2517575171 |
| GSE37065 | Up | 0.3205684876 |
| GSE28863_A1 | Down | -0.1826388608 |
| GSE28863_A2 | Down | -0.1913561228 |
| GSE28863_A3 | Up | 0.0784743098 |
| GSE28863_A4 | Down | -0.1401204079 |
| GSE48662 | Up | 0.2027125771 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT028753 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-877-3p | MIMAT0004950 | MIRT037188 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-1260b | MIMAT0015041 | MIRT052749 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
