HCSGD entry for MAPK14
1. General information
| Official gene symbol | MAPK14 |
|---|---|
| Entrez ID | 1432 |
| Gene full name | mitogen-activated protein kinase 14 |
| Other gene symbols | CSBP CSBP1 CSBP2 CSPB1 EXIP Mxi2 PRKM14 PRKM15 RK SAPK2A p38 p38ALPHA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IEA | biological_process |
| GO:0000187 | Activation of MAPK activity | TAS | biological_process |
| GO:0000902 | Cell morphogenesis | IEA | biological_process |
| GO:0000922 | Spindle pole | IEA | cellular_component |
| GO:0001502 | Cartilage condensation | IEA | biological_process |
| GO:0001525 | Angiogenesis | IEA | biological_process |
| GO:0002062 | Chondrocyte differentiation | IEA | biological_process |
| GO:0002224 | Toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0002756 | MyD88-independent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0004672 | Protein kinase activity | IEA | molecular_function |
| GO:0004674 | Protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0004707 | MAP kinase activity | IDA IEA | molecular_function |
| GO:0004708 | MAP kinase kinase activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | ISS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA TAS | cellular_component |
| GO:0006006 | Glucose metabolic process | IEA | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006357 | Regulation of transcription from RNA polymerase II promoter | ISS | biological_process |
| GO:0006915 | Apoptotic process | IEA | biological_process |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0007178 | Transmembrane receptor protein serine/threonine kinase signaling pathway | IEA | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0010831 | Positive regulation of myotube differentiation | ISS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
| GO:0018105 | Peptidyl-serine phosphorylation | IEA ISS | biological_process |
| GO:0019395 | Fatty acid oxidation | IEA | biological_process |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030316 | Osteoclast differentiation | IEA ISS | biological_process |
| GO:0031663 | Lipopolysaccharide-mediated signaling pathway | IEA | biological_process |
| GO:0032495 | Response to muramyl dipeptide | IEA | biological_process |
| GO:0034134 | Toll-like receptor 2 signaling pathway | TAS | biological_process |
| GO:0034138 | Toll-like receptor 3 signaling pathway | TAS | biological_process |
| GO:0034142 | Toll-like receptor 4 signaling pathway | TAS | biological_process |
| GO:0034146 | Toll-like receptor 5 signaling pathway | TAS | biological_process |
| GO:0034162 | Toll-like receptor 9 signaling pathway | TAS | biological_process |
| GO:0034166 | Toll-like receptor 10 signaling pathway | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | TAS | biological_process |
| GO:0035924 | Cellular response to vascular endothelial growth factor stimulus | IMP | biological_process |
| GO:0038066 | P38MAPK cascade | ISS | biological_process |
| GO:0038123 | Toll-like receptor TLR1:TLR2 signaling pathway | TAS | biological_process |
| GO:0038124 | Toll-like receptor TLR6:TLR2 signaling pathway | TAS | biological_process |
| GO:0042307 | Positive regulation of protein import into nucleus | IEA | biological_process |
| GO:0042692 | Muscle cell differentiation | TAS | biological_process |
| GO:0042770 | Signal transduction in response to DNA damage | IMP | biological_process |
| GO:0043536 | Positive regulation of blood vessel endothelial cell migration | IMP | biological_process |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0045648 | Positive regulation of erythrocyte differentiation | IEA | biological_process |
| GO:0045663 | Positive regulation of myoblast differentiation | ISS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0048010 | Vascular endothelial growth factor receptor signaling pathway | IMP | biological_process |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0051090 | Regulation of sequence-specific DNA binding transcription factor activity | TAS | biological_process |
| GO:0051146 | Striated muscle cell differentiation | IEA | biological_process |
| GO:0051149 | Positive regulation of muscle cell differentiation | TAS | biological_process |
| GO:0051403 | Stress-activated MAPK cascade | TAS | biological_process |
| GO:0051525 | NFAT protein binding | IEA ISS | molecular_function |
| GO:0070935 | 3'-UTR-mediated mRNA stabilization | TAS | biological_process |
| GO:0071479 | Cellular response to ionizing radiation | IMP | biological_process |
| GO:0090090 | Negative regulation of canonical Wnt signaling pathway | IEA | biological_process |
| GO:0090400 | Stress-induced premature senescence | IMP | biological_process |
| GO:1901741 | Positive regulation of myoblast fusion | ISS | biological_process |
| GO:2000379 | Positive regulation of reactive oxygen species metabolic process | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1157526348 | 0.6228063333 | 0.6986299243 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0222137266 |
| GSE13712_SHEAR | Down | -0.0976400087 |
| GSE13712_STATIC | Down | -0.3525100242 |
| GSE19018 | Up | 0.0324702859 |
| GSE19899_A1 | Down | -0.0311858080 |
| GSE19899_A2 | Up | 0.2610288025 |
| PubMed_21979375_A1 | Up | 0.7483816964 |
| PubMed_21979375_A2 | Down | -0.1152857009 |
| GSE35957 | Up | 0.6769950824 |
| GSE36640 | Down | -0.1191787657 |
| GSE54402 | Up | 0.2336804603 |
| GSE9593 | Up | 0.4235984709 |
| GSE43922 | Up | 0.2379753005 |
| GSE24585 | Down | -0.2360400990 |
| GSE37065 | Down | -0.0181509741 |
| GSE28863_A1 | Up | 0.3544779922 |
| GSE28863_A2 | Up | 0.5801072150 |
| GSE28863_A3 | Down | -0.5553446484 |
| GSE28863_A4 | Down | -0.3742793514 |
| GSE48662 | Up | 0.3936640234 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-141-3p | MIMAT0000432 | MIRT006424 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 22101765 |
| hsa-miR-200a-3p | MIMAT0000682 | MIRT006423 | Luciferase reporter assay//Microarray//Western blot | Functional MTI | 22101765 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002610 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002610 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT002950 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 15131085 |
| hsa-miR-125b-5p | MIMAT0000423 | MIRT007066 | ChIP-seq//EMSA//Immunoblot//Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22854965 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-24-3p | MIMAT0000080 | 1 | hsa-miR-24 | 15131085 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 9 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26794818 | MAPK14 was significantly up-regulated (p<0 |
| 25684390 | Furthermore, in silico analysis identified four possible miR-433 target genes associated with cellular senescence: cyclin-dependent kinase 6 (CDK6), MAPK14, E2F3, and CDKN2A |
| 25635535 | Silencing Arg-II or p38alpha in senescent cells recouples eNOS and inhibits IL-6 and IL-8 secretion |
| 25635535 | Silencing Arg-II or p38a or S6K1 inhibits each other in senescence endothelial cells |
| 25573782 | It also includes the stress responsive protein p38MAPK (mitogen-activated protein kinase 14) known to be involved in the regulation of senescence |
| 23974111 | Erlotinib potently inhibited the (auto)phosphorylation of mitogen-activated protein kinase 14 (MAPK14, best known as p38(MAPK)) and SRC family kinases (SFKs) |
| 22797809 | This block resulted from increased amounts of ROS and excessive activation of the mitogen activated kinase p38alpha rather than from defects in the canonical DDR pathway |
| 22521293 | A further complex partner was Mxi2 |
| 22521293 | EMSA with supershift analysis for ETS1 and Mxi2 indicated the involvement of both factors in the protein-DNA interaction |
| 22521293 | SIGNIFICANCE: ETS1, ERK2 and Mxi2 are important complex partners initiating increased p16(INK4a) and p21w(af1/cip1) activation in renal tumor cells |
| 17432596 | We investigated the role of p38alpha stress-kinase in regulation of premature senescence program, stimulated by histone deacetylase inhibitor--sodium butyrate (NaB)--after application to rodent transformed cell lines |
| 17432596 | Investigation was performed on the E1A + cHa-ras transformants selected from mice embryonic fibroblasts null at the p38alpha kinase gene or null fibroblasts at the PPM1D gene, which encoded phosphatase Wip1 |
| 17432596 | Absence of Wip1 led to constitutive activation of p38alpha kinase |
| 17312972 | Microwave-assisted synthesis of N-pyrazole ureas and the p38alpha inhibitor BIRB 796 for study into accelerated cell ageing |
| 17312972 | Derivatization of 4-nitronaphth-1-ol using predominantly microwave heating methods and reaction with an N-pyrazole carbamate provides a rapid route to the N-pyrazole urea BIRB 796 in high purity, as a potent and selective inhibitor of p38alpha mitogen-activated protein kinase for the study of accelerated ageing in Werner syndrome cells |
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