HCSGD entry for CACUL1
1. General information
| Official gene symbol | CACUL1 |
|---|---|
| Entrez ID | 143384 |
| Gene full name | CDK2-associated, cullin domain 1 |
| Other gene symbols | C10orf46 CAC1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000082 | G1/S transition of mitotic cell cycle | IMP | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0006511 | Ubiquitin-dependent protein catabolic process | IEA | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IMP | biological_process |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0031461 | Cullin-RING ubiquitin ligase complex | IEA | cellular_component |
| GO:0031625 | Ubiquitin protein ligase binding | IEA | molecular_function |
| GO:0045860 | Positive regulation of protein kinase activity | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0247582539 | 0.9908101516 | 0.3713173789 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2684620583 |
| GSE13712_SHEAR | Down | -0.1658236088 |
| GSE13712_STATIC | Up | 0.0145110168 |
| GSE19018 | Up | 0.1880034269 |
| GSE19899_A1 | Up | 0.1216081412 |
| GSE19899_A2 | Up | 0.6348066558 |
| PubMed_21979375_A1 | Up | 0.9978984753 |
| PubMed_21979375_A2 | Up | 0.3484371306 |
| GSE35957 | Up | 0.1006029244 |
| GSE36640 | Up | 0.1932777868 |
| GSE54402 | Up | 0.2823549914 |
| GSE9593 | Up | 0.3011549428 |
| GSE43922 | Up | 0.2050342684 |
| GSE24585 | Up | 0.0092035782 |
| GSE37065 | Up | 0.1907776217 |
| GSE28863_A1 | Up | 0.5162537679 |
| GSE28863_A2 | Up | 0.4741033955 |
| GSE28863_A3 | Down | -0.5127194929 |
| GSE28863_A4 | Up | 0.2521108327 |
| GSE48662 | Up | 0.0965812955 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022907 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-106b-3p | MIMAT0004672 | MIRT038577 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049767 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21159650 | MLN4924 is a first-in-class experimental cancer drug that inhibits the NEDD8-activating enzyme, thereby inhibiting cullin-RING E3 ubiquitin ligases and stabilizing many cullin substrates |
| 20978349 | The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells |
| 20978349 | Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover of cyclin E |
| 20516500 | We show that MUS-10 interacts with a core component of the Skp, Cullin, F-box containing (SCF) complex, SCON-3, and that its F-box domain is essential for its function in vivo |
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