HCSGD entry for PSMA8

1. General information

Official gene symbolPSMA8
Entrez ID143471
Gene full nameproteasome (prosome, macropain) subunit, alpha type, 8
Other gene symbolsPSMA7L
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000209Protein polyubiquitinationTASbiological_process
GO:0000278Mitotic cell cycleTASbiological_process
GO:0002474Antigen processing and presentation of peptide antigen via MHC class ITASbiological_process
GO:0002479Antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependentTASbiological_process
GO:0004175Endopeptidase activityIEAmolecular_function
GO:0004298Threonine-type endopeptidase activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006511Ubiquitin-dependent protein catabolic processIEAbiological_process
GO:0006521Regulation of cellular amino acid metabolic processTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016032Viral processTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0016071MRNA metabolic processTASbiological_process
GO:0019773Proteasome core complex, alpha-subunit complexIEAcellular_component
GO:0031145Anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0042590Antigen processing and presentation of exogenous peptide antigen via MHC class ITASbiological_process
GO:0042981Regulation of apoptotic processTASbiological_process
GO:0043066Negative regulation of apoptotic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0051437Positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:0051439Regulation of ubiquitin-protein ligase activity involved in mitotic cell cycleTASbiological_process
GO:1990111Spermatoproteasome complexISScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.70187902060.79540566850.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1197586284
GSE13712_SHEARUp0.1894302406
GSE13712_STATICDown-0.0568908082
GSE19018Up0.0234685602
GSE19899_A1Up0.1843221405
GSE19899_A2Up0.0414290418
PubMed_21979375_A1Down-0.0303345777
PubMed_21979375_A2Down-0.2125327537
GSE35957Up0.1798374685
GSE36640Down-0.1903261679
GSE54402Down-0.0335544505
GSE9593Down-0.1800196216
GSE43922Up0.0189098282
GSE24585Up0.0633907325
GSE37065Up0.0182765907
GSE28863_A1Up0.0356062031
GSE28863_A2Down-0.1074422989
GSE28863_A3Up0.1245653715
GSE28863_A4Up0.0698987338
GSE48662Up0.0095655635

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.