HCSGD entry for CSF2

1. General information

Official gene symbolCSF2
Entrez ID1437
Gene full namecolony stimulating factor 2 (granulocyte-macrophage)
Other gene symbolsGMCSF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001892Embryonic placenta developmentIEAbiological_process
GO:0005125Cytokine activityIEAmolecular_function
GO:0005129Granulocyte macrophage colony-stimulating factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0006955Immune responseIEAbiological_process
GO:0008083Growth factor activityIEAmolecular_function
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010628Positive regulation of gene expressionIDAbiological_process
GO:0010744Positive regulation of macrophage derived foam cell differentiationIDAbiological_process
GO:0032747Positive regulation of interleukin-23 productionIDAbiological_process
GO:0042045Epithelial fluid transportIEAbiological_process
GO:0042116Macrophage activationIEAbiological_process
GO:0042523Positive regulation of tyrosine phosphorylation of Stat5 proteinIDAbiological_process
GO:0043011Myeloid dendritic cell differentiationIEAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0045918Negative regulation of cytolysisIDAbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071803Positive regulation of podosome assemblyIDAbiological_process
GO:0097028Dendritic cell differentiationIDAbiological_process
GO:2001240Negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00023893470.99361611260.04397902101.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3605099135
GSE13712_SHEARUp0.2481796732
GSE13712_STATICUp0.4005601548
GSE19018Up0.3083595895
GSE19899_A1Up2.6224523734
GSE19899_A2Up4.5476987246
PubMed_21979375_A1Up4.7722643182
PubMed_21979375_A2Up2.7836145194
GSE35957Up0.7304866561
GSE36640Up0.0652921093
GSE54402Up3.8603705860
GSE9593Up0.1736588768
GSE43922Up1.6984421010
GSE24585Down-0.1095237585
GSE37065Up0.1605170354
GSE28863_A1Down-0.0157139167
GSE28863_A2Up0.0205372065
GSE28863_A3Up0.1894684863
GSE28863_A4Down-0.0937467628
GSE48662Up0.0026351855

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

KB002DB05194 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25548483Senescent hepatocyte-conditioned medium elicited migration of inflammatory (granulocyte-macrophage colony stimulating factor, GM-CSF-derived), but not non-inflammatory (CSF-1-derived) human macrophages (P = 0
24813621Senescent cancer cells exerted bystander effects by promoting the invasion and migration of unirradiated cells through the release of CSF2 and the subsequently activation of the JAK2-STAT3 and AKT pathways
24434012Multiplex analysis revealed that multiple cytokines are increased in BPH, including GM-CSF, IL-1alpha, and IL-4, and that these are also increased in senescent prostatic epithelial cells in vitro
18702309To evaluate the effect of gamma-irradiation to transgene expression in tumor cells we constructed several stably transfected clones of human and mouse cell lines expressing transgenic GM-CSF or GFP under control of IE-CMV promoter
18702309Moreover, amount of the secreted GM-CSF as well as MFI in GFP-expressing cells significantly increases after gamma-irradiation up to 10 fold for cells exposed with 100 Gr
17686517Rapid cell senescence and apoptosis in lymphocytes and granulocytes and absence of GM-CSF receptor in congenital dysgranulopoietic neutropenia
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