HCSGD entry for CST3

1. General information

Official gene symbolCST3
Entrez ID1471
Gene full namecystatin C
Other gene symbolsARMD11
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001540Beta-amyloid bindingIPImolecular_function
GO:0001654Eye developmentIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001775Cell activationIEAbiological_process
GO:0002020Protease bindingIPImolecular_function
GO:0004866Endopeptidase inhibitor activityIDAmolecular_function
GO:0004869Cysteine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIMP TAScellular_component
GO:0005604Basement membraneIEAcellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005764LysosomeIEAcellular_component
GO:0005771Multivesicular bodyIEAcellular_component
GO:0005783Endoplasmic reticulumIEAcellular_component
GO:0006915Apoptotic processIEAbiological_process
GO:0006952Defense responseIDAbiological_process
GO:0007420Brain developmentIEAbiological_process
GO:0007431Salivary gland developmentIEAbiological_process
GO:0007566Embryo implantationIEAbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0009743Response to carbohydrateIEAbiological_process
GO:0010466Negative regulation of peptidase activityIDAbiological_process
GO:0010703Negative regulation of histolysisICbiological_process
GO:0010711Negative regulation of collagen catabolic processIEPbiological_process
GO:0010716Negative regulation of extracellular matrix disassemblyIEPbiological_process
GO:0010951Negative regulation of endopeptidase activityIDAbiological_process
GO:0031667Response to nutrient levelsIEAbiological_process
GO:0031965Nuclear membraneIEAcellular_component
GO:0031982VesicleIEAcellular_component
GO:0032355Response to estradiolIEAbiological_process
GO:0034103Regulation of tissue remodelingIEPbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042747Circadian sleep/wake cycle, REM sleepIEAbiological_process
GO:0042995Cell projectionIEAcellular_component
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043067Regulation of programmed cell deathIEAbiological_process
GO:0043206Extracellular fibril organizationIGIbiological_process
GO:0043292Contractile fiberIEAcellular_component
GO:0045740Positive regulation of DNA replicationIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0048678Response to axon injuryIEAbiological_process
GO:0052548Regulation of endopeptidase activityIDAbiological_process
GO:0060009Sertoli cell developmentIEAbiological_process
GO:0060311Negative regulation of elastin catabolic processIMPbiological_process
GO:0060313Negative regulation of blood vessel remodelingIEPbiological_process
GO:0060548Negative regulation of cell deathIEAbiological_process
GO:0070301Cellular response to hydrogen peroxideIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00656389570.98588392540.21369097651.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2557726674
GSE13712_SHEARUp0.2335101868
GSE13712_STATICUp0.1304920798
GSE19018Up0.3175907887
GSE19899_A1Up0.5983800808
GSE19899_A2Up0.9830078744
PubMed_21979375_A1Up0.9030682116
PubMed_21979375_A2Up1.2950355789
GSE35957Down-0.3300158937
GSE36640Up1.7717152753
GSE54402Down-0.2824786530
GSE9593Up0.3053631475
GSE43922Up0.4615661853
GSE24585Up0.0522590094
GSE37065Up0.0959045602
GSE28863_A1Up0.1515506588
GSE28863_A2Up0.3722110023
GSE28863_A3Up0.0273192389
GSE28863_A4Down-0.0065815672
GSE48662Up0.4529647982

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019152MicroarrayFunctional MTI (Weak)18185580
hsa-miR-26b-5pMIMAT0000083MIRT030271MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.