HCSGD entry for ADRA1A

1. General information

Official gene symbolADRA1A
Entrez ID148
Gene full nameadrenoceptor alpha 1A
Other gene symbolsADRA1C ADRA1L1 ALPHA1AAR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001985Negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressureIEAbiological_process
GO:0001994Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureIEAbiological_process
GO:0001996Positive regulation of heart rate by epinephrine-norepinephrineIEAbiological_process
GO:0001997Positive regulation of the force of heart contraction by epinephrine-norepinephrineIEAbiological_process
GO:0003084Positive regulation of systemic arterial blood pressureIEAbiological_process
GO:0004937Alpha1-adrenergic receptor activityIEA ISS NAS TASmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006915Apoptotic processTASbiological_process
GO:0006939Smooth muscle contractionTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007200Phospholipase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007202Activation of phospholipase C activityISSbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationISSbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0007512Adult heart developmentIEAbiological_process
GO:0007568AgingISSbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0009725Response to hormoneISSbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016049Cell growthIEAbiological_process
GO:0019229Regulation of vasoconstrictionIEAbiological_process
GO:0030018Z discIEAcellular_component
GO:0030315T-tubuleIEAcellular_component
GO:0031965Nuclear membraneIDAcellular_component
GO:0032229Negative regulation of synaptic transmission, GABAergicISSbiological_process
GO:0035024Negative regulation of Rho protein signal transductionISSbiological_process
GO:0035265Organ growthIEAbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0042493Response to drugISSbiological_process
GO:0043410Positive regulation of MAPK cascadeIDAbiological_process
GO:0045760Positive regulation of action potentialISSbiological_process
GO:0045907Positive regulation of vasoconstrictionISSbiological_process
GO:0045987Positive regulation of smooth muscle contractionIEAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
GO:0055117Regulation of cardiac muscle contractionIEAbiological_process
GO:0060073MicturitionIEAbiological_process
GO:0060402Calcium ion transport into cytosolISSbiological_process
GO:0060452Positive regulation of cardiac muscle contractionISSbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0071875Adrenergic receptor signaling pathwayISS NAS TASbiological_process
GO:0090037Positive regulation of protein kinase C signalingISSbiological_process
GO:0097195Pilomotor reflexIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81202368070.86844629760.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0626323872
GSE13712_SHEARDown-0.0454849599
GSE13712_STATICUp0.0824033150
GSE19018Up0.0731499858
GSE19899_A1Up0.0752021210
GSE19899_A2Up0.1233978960
PubMed_21979375_A1Down-0.0987891488
PubMed_21979375_A2Down-0.0344713930
GSE35957Up0.0826366229
GSE36640Up0.0029341206
GSE54402Up0.0215088953
GSE9593Down-0.0515121435
GSE43922Up0.0113509018
GSE24585Up0.1162310362
GSE37065Down-0.0266312938
GSE28863_A1Down-0.0478245813
GSE28863_A2Down-0.0288906951
GSE28863_A3Up0.3401890972
GSE28863_A4Down-0.0242387674
GSE48662Down-0.0153165138

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-484MIMAT0002174MIRT041983CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.