HCSGD entry for CTBP1
1. General information
| Official gene symbol | CTBP1 |
|---|---|
| Entrez ID | 1487 |
| Gene full name | C-terminal binding protein 1 |
| Other gene symbols | BARS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IMP | biological_process |
| GO:0001106 | RNA polymerase II transcription corepressor activity | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA ISS | cellular_component |
| GO:0005667 | Transcription factor complex | IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007030 | Golgi organization | IEA | biological_process |
| GO:0008022 | Protein C-terminus binding | TAS | molecular_function |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0016616 | Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | IEA | molecular_function |
| GO:0017053 | Transcriptional repressor complex | IDA ISS | cellular_component |
| GO:0019079 | Viral genome replication | TAS | biological_process |
| GO:0019904 | Protein domain specific binding | IDA IPI | molecular_function |
| GO:0031065 | Positive regulation of histone deacetylation | IMP | biological_process |
| GO:0034401 | Regulation of transcription by chromatin organization | IMP | biological_process |
| GO:0035067 | Negative regulation of histone acetylation | IMP | biological_process |
| GO:0042803 | Protein homodimerization activity | IEA | molecular_function |
| GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0048037 | Cofactor binding | IEA | molecular_function |
| GO:0050872 | White fat cell differentiation | ISS | biological_process |
| GO:0051287 | NAD binding | IEA ISS | molecular_function |
| GO:0051726 | Regulation of cell cycle | IMP | biological_process |
| GO:0070491 | Repressing transcription factor binding | IPI | molecular_function |
| GO:0090241 | Negative regulation of histone H4 acetylation | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9616438889 | 0.2793755822 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0573966207 |
| GSE13712_SHEAR | Up | 0.0135820626 |
| GSE13712_STATIC | Down | -0.0443050759 |
| GSE19018 | Down | -0.0696957006 |
| GSE19899_A1 | Down | -0.4406888879 |
| GSE19899_A2 | Up | 0.1109607898 |
| PubMed_21979375_A1 | Down | -0.4334559975 |
| PubMed_21979375_A2 | Down | -0.0464208481 |
| GSE35957 | Down | -0.0079899408 |
| GSE36640 | Down | -0.3253922084 |
| GSE54402 | Up | 0.0902204805 |
| GSE9593 | Down | -0.1146061881 |
| GSE43922 | Down | -0.0222292942 |
| GSE24585 | Down | -0.1109844087 |
| GSE37065 | Down | -0.1919722142 |
| GSE28863_A1 | Up | 0.0635609564 |
| GSE28863_A2 | Up | 0.0416597852 |
| GSE28863_A3 | Up | 0.0748147022 |
| GSE28863_A4 | Down | -0.0187161853 |
| GSE48662 | Down | -0.1264722684 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Formic Acid | DB01942 | EXPT01461 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-137 | MIMAT0000429 | MIRT005605 | Luciferase reporter assay//qRT-PCR//Western blot//Reporter assay;Other | Functional MTI | 21278922 |
| hsa-miR-1 | MIMAT0000416 | MIRT024026 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-940 | MIMAT0004983 | MIRT036611 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10b-5p | MIMAT0000254 | MIRT047493 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-26a-5p | MIMAT0000082 | MIRT050145 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
