HCSGD entry for PTPRVP
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
Not in the Gene Ontology
4. Expression levels in datasets
Individual experiment result ( "-" represent NA in the specific microarray platform )
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles:
1 abstracts the gene occurs . PubMed ID of the article Sentenece the gene occurs 16258284 PTPRV is a key mediator of p53-induced cell cycle exit 16258284 We have recently reported the identification of a new direct p53 target, Ptprv, encoding a transmembrane tyrosine phosphatase 16258284 Ptprv expression is dramatically and preferentially increased in cells undergoing p53-dependent cell cycle exit, but not in cells undergoing p53-mediated apoptosis 16258284 Importantly, while p53-induced apoptosis is intact in mice lacking Ptprv, Ptprv-null cells are defective in G1 checkpoint control 16258284 In addition, we report herein that Ptprv is induced at high cell density and mediates contact inhibition of cell growth 16258284 Together, the data suggest that Ptprv is a potent inhibitor of cell proliferation and a critical mediator of p53-induced cell cycle exit
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