HCSGD entry for CTH

1. General information

Official gene symbolCTH
Entrez ID1491
Gene full namecystathionase (cystathionine gamma-lyase)
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000096Sulfur amino acid metabolic processTASbiological_process
GO:0000098Sulfur amino acid catabolic processTASbiological_process
GO:0004123Cystathionine gamma-lyase activityIDA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006534Cysteine metabolic processTASbiological_process
GO:0016846Carbon-sulfur lyase activityTASmolecular_function
GO:0018272Protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysineIDAbiological_process
GO:0019344Cysteine biosynthetic processIDA IEAbiological_process
GO:0019346TranssulfurationTASbiological_process
GO:0030170Pyridoxal phosphate bindingIDAmolecular_function
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0034641Cellular nitrogen compound metabolic processTASbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0044524Protein sulfhydrationIMPbiological_process
GO:0044540L-cystine L-cysteine-lyase (deaminating)IMPmolecular_function
GO:0047982Homocysteine desulfhydrase activityTASmolecular_function
GO:0051092Positive regulation of NF-kappaB transcription factor activityIEAbiological_process
GO:0051289Protein homotetramerizationIPIbiological_process
GO:0070814Hydrogen sulfide biosynthetic processIDAbiological_process
GO:0080146L-cysteine desulfhydrase activityTASmolecular_function
GO:2001234Negative regulation of apoptotic signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01316772920.09571101780.28549242170.5901170532

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2411274875
GSE13712_SHEARUp0.3387664894
GSE13712_STATICDown-0.4588797025
GSE19018Up0.5756043730
GSE19899_A1Up0.4303565168
GSE19899_A2Up0.2186081104
PubMed_21979375_A1Up1.3940360129
PubMed_21979375_A2Down-0.4864947716
GSE35957Down-0.8259262330
GSE36640Down-0.1127726308
GSE54402Up0.5004258995
GSE9593Up0.0707359636
GSE43922Up1.0009514640
GSE24585Up2.0846552543
GSE37065Down-0.2022673530
GSE28863_A1Down-0.5792789175
GSE28863_A2Down-0.7426999575
GSE28863_A3Down-0.2286888915
GSE28863_A4Down-0.2971988478
GSE48662Up0.4750419255

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-CysteineDB00151 NUTR00018 | DB04443
2-[(3-Hydroxy-2-Methyl-5-Phosphonooxymethyl-Pyridin-4-Ylmethyl)-Imino]-5-Phosphono-Pent-3-Enoic AcidDB02328 EXPT01727
Carboxymethylthio-3-(3-Chlorophenyl)-1,2,4-OxadiazolDB03928 EXPT00861
L-2-amino-3-butynoic acidDB04217 EXPT02057

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT019085MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024887MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026956MicroarrayFunctional MTI (Weak)19074876
hsa-miR-26b-5pMIMAT0000083MIRT030353MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.