HCSGD entry for CYP19A1
1. General information
| Official gene symbol | CYP19A1 |
|---|---|
| Entrez ID | 1588 |
| Gene full name | cytochrome P450, family 19, subfamily A, polypeptide 1 |
| Other gene symbols | ARO ARO1 CPV1 CYAR CYP19 CYPXIX P-450AROM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | TAS | cellular_component |
| GO:0006694 | Steroid biosynthetic process | TAS | biological_process |
| GO:0006703 | Estrogen biosynthetic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0008209 | Androgen metabolic process | IEA | biological_process |
| GO:0009055 | Electron carrier activity | TAS | molecular_function |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016125 | Sterol metabolic process | TAS | biological_process |
| GO:0016705 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | IEA | molecular_function |
| GO:0016712 | Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | IEA TAS | molecular_function |
| GO:0019825 | Oxygen binding | TAS | molecular_function |
| GO:0020037 | Heme binding | IDA IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0060736 | Prostate gland growth | IEA | biological_process |
| GO:0070330 | Aromatase activity | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3988908590 | 0.9636384560 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0249640518 |
| GSE13712_SHEAR | Up | 0.0533097796 |
| GSE13712_STATIC | Down | -0.0135379408 |
| GSE19018 | Up | 0.0218801342 |
| GSE19899_A1 | Up | 0.0478754079 |
| GSE19899_A2 | Up | 0.0286335142 |
| PubMed_21979375_A1 | Up | 0.0762258933 |
| PubMed_21979375_A2 | Up | 0.1001320941 |
| GSE35957 | Up | 0.0810024202 |
| GSE36640 | Up | 0.0207378186 |
| GSE54402 | Up | 0.0880144052 |
| GSE9593 | Down | -0.0316879697 |
| GSE43922 | Up | 0.2392928832 |
| GSE24585 | Up | 0.0095430214 |
| GSE37065 | Up | 0.1359041566 |
| GSE28863_A1 | Up | 0.0330876769 |
| GSE28863_A2 | Up | 0.3796364411 |
| GSE28863_A3 | Up | 0.2660423819 |
| GSE28863_A4 | Down | -0.0497207091 |
| GSE48662 | Down | -0.0188882430 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| Nicotine | DB00184 | APRD00200 | EXPT02315 | DB09463 |
| Exemestane | DB00990 | APRD00144 |
| Letrozole | DB01006 | APRD01066 |
| Ketoconazole | DB01026 | APRD00401 |
| Anastrozole | DB01217 | APRD00016 |
| 2-Methoxyestradiol | DB02342 | EXPT01362 |
| atamestane-plus-toremifene | DB05338 | - |
| MPI-674 | DB05749 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-let-7f-5p | MIMAT0000067 | MIRT006943 | Luciferase reporter assay | Functional MTI | 22407818 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT007270 | Luciferase reporter assay | Functional MTI | 23438603 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT007271 | Luciferase reporter assay | Functional MTI | 23438603 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT017035 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21613412 | Endocrine therapies that target estrogen receptor alpha (ERalpha) action (tamoxifen, toremifene, fulvestrant) or estrogen synthesis (aromatase inhibitors: letrozole, anastrozole, exemestane; or ovarian suppression) are a clinical mainstay |
| 18429962 | We confirmed the overexpression of those miRNAs by Northern blot analysis in ARO and FRO cells |
| 18429962 | To investigate the functional role of these miRNAs in ATC cells, ARO and FRO cells were transfected with miRNA inhibitors, antisense oligonucleotides containing locked nucleic acids |
| 16392960 | Cell growth assays, colony formation assays and xenograft models were used to quantify the radiosensitizing effect of Gleevec in cells of the anaplastic thyroid cancer cell lines ARO and FRO |
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