HCSGD entry for ADSS
1. General information
| Official gene symbol | ADSS |
|---|---|
| Entrez ID | 159 |
| Gene full name | adenylosuccinate synthase |
| Other gene symbols | ADEH ADSS 2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IEA | molecular_function |
| GO:0002376 | Immune system process | NAS | biological_process |
| GO:0004019 | Adenylosuccinate synthase activity | IDA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005525 | GTP binding | NAS | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006167 | AMP biosynthetic process | IDA NAS | biological_process |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0006531 | Aspartate metabolic process | IEA | biological_process |
| GO:0009168 | Purine ribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0014074 | Response to purine-containing compound | IEA | biological_process |
| GO:0042301 | Phosphate ion binding | NAS | molecular_function |
| GO:0044208 | 'de novo' AMP biosynthetic process | IEA | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046040 | IMP metabolic process | IEA | biological_process |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
| GO:0060359 | Response to ammonium ion | IEA | biological_process |
| GO:0071257 | Cellular response to electrical stimulus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8026191406 | 0.2036837316 | 0.9999902473 | 0.8738646292 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0323989506 |
| GSE13712_SHEAR | Up | 0.0392213015 |
| GSE13712_STATIC | Down | -0.1683546137 |
| GSE19018 | Up | 0.0131644442 |
| GSE19899_A1 | Up | 0.1744582598 |
| GSE19899_A2 | Down | -0.3656551121 |
| PubMed_21979375_A1 | Up | 0.5727660549 |
| PubMed_21979375_A2 | Down | -0.3468775881 |
| GSE35957 | Up | 0.1950196081 |
| GSE36640 | Up | 0.0091260839 |
| GSE54402 | Up | 0.0679232896 |
| GSE9593 | Up | 0.0579351826 |
| GSE43922 | Up | 0.0810031891 |
| GSE24585 | Down | -0.2024993384 |
| GSE37065 | Up | 0.1208008571 |
| GSE28863_A1 | Down | -0.1523628097 |
| GSE28863_A2 | Up | 0.1199727864 |
| GSE28863_A3 | Down | -0.4350788064 |
| GSE28863_A4 | Down | -0.2379324217 |
| GSE48662 | Down | -0.5676744809 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| L-Aspartic Acid | DB00128 | NUTR00016 | EXPT01823 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT001480 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-96-5p | MIMAT0000095 | MIRT027907 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-20a-5p | MIMAT0000075 | MIRT050584 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
