HCSGD entry for CYP27B1
1. General information
| Official gene symbol | CYP27B1 |
|---|---|
| Entrez ID | 1594 |
| Gene full name | cytochrome P450, family 27, subfamily B, polypeptide 1 |
| Other gene symbols | CP2B CYP1 CYP1alpha CYP27B P450c1 PDDR VDD1 VDDR VDDRI VDR |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004498 | Calcidiol 1-monooxygenase activity | IDA IEA | molecular_function |
| GO:0005506 | Iron ion binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005739 | Mitochondrion | IEA ISS TAS | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006805 | Xenobiotic metabolic process | TAS | biological_process |
| GO:0006816 | Calcium ion transport | IEA ISS | biological_process |
| GO:0008202 | Steroid metabolic process | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IDA | biological_process |
| GO:0010956 | Negative regulation of calcidiol 1-monooxygenase activity | IDA | biological_process |
| GO:0010980 | Positive regulation of vitamin D 24-hydroxylase activity | IDA | biological_process |
| GO:0020037 | Heme binding | IEA | molecular_function |
| GO:0030282 | Bone mineralization | IEP | biological_process |
| GO:0030308 | Negative regulation of cell growth | IMP | biological_process |
| GO:0030500 | Regulation of bone mineralization | IMP | biological_process |
| GO:0032496 | Response to lipopolysaccharide | IDA | biological_process |
| GO:0033280 | Response to vitamin D | IDA IEA | biological_process |
| GO:0034341 | Response to interferon-gamma | IDA | biological_process |
| GO:0036378 | Calcitriol biosynthetic process from calciol | IDA | biological_process |
| GO:0042359 | Vitamin D metabolic process | IDA TAS | biological_process |
| GO:0042369 | Vitamin D catabolic process | IEA | biological_process |
| GO:0043627 | Response to estrogen | IEP | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0045618 | Positive regulation of keratinocyte differentiation | IMP | biological_process |
| GO:0046697 | Decidualization | IEP | biological_process |
| GO:0055074 | Calcium ion homeostasis | IMP | biological_process |
| GO:0070314 | G1 to G0 transition | IMP | biological_process |
| GO:0070564 | Positive regulation of vitamin D receptor signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2808746134 | 0.7860919266 | 0.9782851264 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0348453143 |
| GSE13712_SHEAR | Up | 0.2662825293 |
| GSE13712_STATIC | Up | 0.2091579650 |
| GSE19018 | Down | -0.1192851241 |
| GSE19899_A1 | Up | 0.0820190428 |
| GSE19899_A2 | Up | 0.1322317283 |
| PubMed_21979375_A1 | Up | 0.0187663616 |
| PubMed_21979375_A2 | Up | 0.2968075908 |
| GSE35957 | Down | -0.1185611882 |
| GSE36640 | Up | 0.2593573698 |
| GSE54402 | Up | 0.2923136339 |
| GSE9593 | Down | -0.0449880700 |
| GSE43922 | Up | 0.0272178766 |
| GSE24585 | Down | -0.1017231161 |
| GSE37065 | Up | 0.0267273142 |
| GSE28863_A1 | Down | -0.0928217901 |
| GSE28863_A2 | Down | -0.1942476060 |
| GSE28863_A3 | Up | 0.1070767222 |
| GSE28863_A4 | Up | 0.2700205199 |
| GSE48662 | Down | -0.2257205207 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029947 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-31-5p | MIMAT0000089 | MIRT049861 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT051080 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26790152 | In this study, we investigated whether 1,25(OH)2D3 deficiency has an impact on the colon of 25-hydroxyvitamin D 1alpha-hydroxylase knockout [Cyp27b1(-/-)] mice fed on a rescue diet (high calcium, phosphate, and lactose) from weaning to 10 months of age |
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