HCSGD entry for ACE

1. General information

Official gene symbolACE
Entrez ID1636
Gene full nameangiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Other gene symbolsACE1 CD143 DCP DCP1 ICH MVCD3
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001822Kidney developmentIMPbiological_process
GO:0001974Blood vessel remodelingICbiological_process
GO:0002003Angiotensin maturationTASbiological_process
GO:0002005Angiotensin catabolic process in bloodICbiological_process
GO:0002019Regulation of renal output by angiotensinICbiological_process
GO:0003081Regulation of systemic arterial blood pressure by renin-angiotensinICbiological_process
GO:0003779Actin bindingIDAmolecular_function
GO:0004175Endopeptidase activityIDAmolecular_function
GO:0004180Carboxypeptidase activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0006508ProteolysisIEAbiological_process
GO:0008144Drug bindingIDAmolecular_function
GO:0008217Regulation of blood pressureISSbiological_process
GO:0008237Metallopeptidase activityIDA IEA ISSmolecular_function
GO:0008241Peptidyl-dipeptidase activityIDA IEA ISSmolecular_function
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0009897External side of plasma membraneIDAcellular_component
GO:0014910Regulation of smooth muscle cell migrationISSbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019229Regulation of vasoconstrictionICbiological_process
GO:0031404Chloride ion bindingIDAmolecular_function
GO:0031711Bradykinin receptor bindingIPImolecular_function
GO:0032943Mononuclear cell proliferationICbiological_process
GO:0042312Regulation of vasodilationICbiological_process
GO:0042447Hormone catabolic processIDA ISSbiological_process
GO:0043171Peptide catabolic processIDAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0050482Arachidonic acid secretionIDAbiological_process
GO:0060218Hematopoietic stem cell differentiationICbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.43914691690.51258637970.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1778499456
GSE13712_SHEARDown-0.5375347011
GSE13712_STATICDown-1.1833530292
GSE19018Up0.1253715877
GSE19899_A1Up0.0145449163
GSE19899_A2Up0.0583348992
PubMed_21979375_A1Down-0.2046219548
PubMed_21979375_A2Down-0.1221358942
GSE35957Up0.0729575638
GSE36640Up0.1132008679
GSE54402Down-0.0398432018
GSE9593Up0.1391036859
GSE43922Up0.0389943773
GSE24585Up0.3566282586
GSE37065Down-0.1822144904
GSE28863_A1Up0.2590164062
GSE28863_A2Up0.2212963940
GSE28863_A3Up0.2735300632
GSE28863_A4Up0.1225693706
GSE48662Up0.1958720509

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RamiprilDB00178 APRD00009
TrandolaprilDB00519 APRD01269
BenazeprilDB00542 APRD00063
MoexiprilDB00691 APRD01120
LisinoprilDB00722 APRD00560
PerindoprilDB00790 APRD01178
QuinaprilDB00881 APRD00523
OmapatrilatDB00886 APRD00443
RescinnamineDB01180 APRD00112
CilazaprilDB01340 -
SpiraprilDB01348 -
1-(3-Mercapto-2-Methyl-Propionyl)-Pyrrolidine-2-Carboxylic AcidDB02032 EXPT02137
N-acetyl-alpha-D-glucosamineDB03740 EXPT02319
TemocaprilDB08836 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018383MicroarrayFunctional MTI (Weak)18185580
Entries Per Page
Displaying Page of
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.