HCSGD entry for DCX
1. General information
| Official gene symbol | DCX |
|---|---|
| Entrez ID | 1641 |
| Gene full name | doublecortin |
| Other gene symbols | DBCN DC LISX SCLH XLIS |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001764 | Neuron migration | IDA IEA | biological_process |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | TAS | cellular_component |
| GO:0005874 | Microtubule | IEA | cellular_component |
| GO:0005875 | Microtubule associated complex | TAS | cellular_component |
| GO:0007399 | Nervous system development | TAS | biological_process |
| GO:0007411 | Axon guidance | TAS | biological_process |
| GO:0007417 | Central nervous system development | TAS | biological_process |
| GO:0007420 | Brain development | IEA | biological_process |
| GO:0008017 | Microtubule binding | IDA | molecular_function |
| GO:0019901 | Protein kinase binding | IPI | molecular_function |
| GO:0021952 | Central nervous system projection neuron axonogenesis | IEA | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0043005 | Neuron projection | IDA | cellular_component |
| GO:0048675 | Axon extension | IEA | biological_process |
| GO:0048813 | Dendrite morphogenesis | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6630754455 | 0.8041551727 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0562832108 |
| GSE13712_SHEAR | Down | -0.0132753198 |
| GSE13712_STATIC | Down | -0.1343364557 |
| GSE19018 | Up | 0.1624018244 |
| GSE19899_A1 | Up | 0.1723601073 |
| GSE19899_A2 | Up | 0.2039737010 |
| PubMed_21979375_A1 | Down | -0.0398741817 |
| PubMed_21979375_A2 | Down | -0.1296331570 |
| GSE35957 | Up | 0.2287222177 |
| GSE36640 | Down | -0.0562461929 |
| GSE54402 | Up | 0.0979018564 |
| GSE9593 | Down | -0.0728361224 |
| GSE43922 | Up | 0.0519542657 |
| GSE24585 | Down | -0.2632453532 |
| GSE37065 | Down | -0.0383203167 |
| GSE28863_A1 | Down | -0.1006511599 |
| GSE28863_A2 | Down | -0.0022124195 |
| GSE28863_A3 | Up | 0.2637655938 |
| GSE28863_A4 | Up | 0.0088149022 |
| GSE48662 | Down | -0.0514658214 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT001070 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 19713529 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 18358537 | An OBGF400 neuronal phenotype was indicated by the recognition of a transfected neuronal progenitor-cell-specific tubulin-alpha1 gene promoter, intracellular presence of early neuronal markers (TuJ1, neuregulin-1, doublecortin and SOX2) and enhanced expression of neuronal- and progenitor lineage-active genes (MAP2, nestin, ENO and Syn1) compared to that of porcine epithelial cells |
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