HCSGD entry for AKR1C2

1. General information

Official gene symbolAKR1C2
Entrez ID1646
Gene full namealdo-keto reductase family 1, member C2
Other gene symbolsAKR1C-pseudo BABP DD DD2 DDH2 HAKRD HBAB MCDR2 SRXY8
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004032Alditol:NADP+ 1-oxidoreductase activityIDAmolecular_function
GO:0004958Prostaglandin F receptor activityIDAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0006693Prostaglandin metabolic processIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007586DigestionIDAbiological_process
GO:0008202Steroid metabolic processIDAbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0016655Oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorIDAmolecular_function
GO:0018636Phenanthrene 9,10-monooxygenase activityIDAmolecular_function
GO:0031406Carboxylic acid bindingIDAmolecular_function
GO:0032052Bile acid bindingIDAmolecular_function
GO:0034694Response to prostaglandinIDAbiological_process
GO:0042448Progesterone metabolic processIDAbiological_process
GO:0044597Daunorubicin metabolic processIMPbiological_process
GO:0044598Doxorubicin metabolic processIMPbiological_process
GO:0047086Ketosteroid monooxygenase activityIDAmolecular_function
GO:0047115Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityIDAmolecular_function
GO:0051897Positive regulation of protein kinase B signalingIDAbiological_process
GO:0055114Oxidation-reduction processIDAbiological_process
GO:0071395Cellular response to jasmonic acid stimulusIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00113599790.32170593440.09052084591.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.7992628312
GSE13712_SHEARDown-1.0000232038
GSE13712_STATICDown-0.3397069221
GSE19018Down-0.9796821866
GSE19899_A1Down-0.1499809702
GSE19899_A2Down-1.4450921051
PubMed_21979375_A1Up0.5779069128
PubMed_21979375_A2Down-0.0594353470
GSE35957Down-0.1530004972
GSE36640Up0.9823755070
GSE54402Up0.1562546682
GSE9593Up0.2734880044
GSE43922Down-0.0804344855
GSE24585Up0.6790524053
GSE37065Up0.8771550138
GSE28863_A1Up2.2853319898
GSE28863_A2Up3.0392457927
GSE28863_A3Up0.2674279331
GSE28863_A4Up0.4924303582
GSE48662--

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

NADHDB00157 NUTR00041 | DB01907 | EXPT02287 | DB03527
2'-Monophosphoadenosine 5'-DiphosphoriboseDB03461 EXPT02293
(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONEDB07768 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT006986Luciferase reporter assay//Reporter assay;ProteomicsFunctional MTI21512034
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.