HCSGD entry for ASXL1

1. General information

Official gene symbolASXL1
Entrez ID171023
Gene full nameadditional sex combs like 1 (Drosophila)
Other gene symbolsBOPS MDS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000790Nuclear chromatinISScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0003713Transcription coactivator activityISSmolecular_function
GO:0003714Transcription corepressor activityISSmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0032526Response to retinoic acidISSbiological_process
GO:0035359Negative regulation of peroxisome proliferator activated receptor signaling pathwayISSbiological_process
GO:0035517PR-DUB complexIDAcellular_component
GO:0035522Monoubiquitinated histone H2A deubiquitinationIDAbiological_process
GO:0042974Retinoic acid receptor bindingISSmolecular_function
GO:0042975Peroxisome proliferator activated receptor bindingISSmolecular_function
GO:0045599Negative regulation of fat cell differentiationISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048386Positive regulation of retinoic acid receptor signaling pathwayISSbiological_process
GO:0048387Negative regulation of retinoic acid receptor signaling pathwayISSbiological_process
GO:0060348Bone developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28405282090.60592728240.98308830641.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3158216601
GSE13712_SHEARUp0.2689170401
GSE13712_STATICDown-0.3036162324
GSE19018Up0.0899277810
GSE19899_A1Down-0.2974214896
GSE19899_A2Up0.0350299544
PubMed_21979375_A1Up0.2867924092
PubMed_21979375_A2Up0.2428084997
GSE35957Down-0.4052254008
GSE36640Down-0.3171723320
GSE54402Up0.0321838251
GSE9593Up0.0001777660
GSE43922Up0.0437668190
GSE24585Up0.1497000613
GSE37065Down-0.2062157521
GSE28863_A1Up0.6486989081
GSE28863_A2Up0.6597523326
GSE28863_A3Up0.0921865234
GSE28863_A4Up0.0863812811
GSE48662Up0.1316475519

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-193b-3pMIMAT0002819MIRT041588CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT042036CLASHFunctional MTI (Weak)23622248
hsa-miR-331-3pMIMAT0000760MIRT043339CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27147278Prominent examples include aberrations in cytokines and their signaling pathways (such as tumor necrosis factor-alpha, interferon-gamma, SMAD proteins), mutations in genes encoding the RNA splicing machinery (SF3B1, SRSF2, ZRSR2, and U2AF1 genes), mutations in genes disrupting the epigenetic machinery (TET2, DNMT3A, DNMT3B, EZH2, ASXL1)
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