HCSGD entry for DHPS
1. General information
| Official gene symbol | DHPS |
|---|---|
| Entrez ID | 1725 |
| Gene full name | deoxyhypusine synthase |
| Other gene symbols | DHS DS MIG13 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0008612 | Peptidyl-lysine modification to hypusine | IEA TAS | biological_process |
| GO:0034038 | Deoxyhypusine synthase activity | IEA TAS | molecular_function |
| GO:0043687 | Post-translational protein modification | TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0050983 | Deoxyhypusine biosynthetic process from spermidine | IEA | biological_process |
| GO:0051289 | Protein homotetramerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5715925269 | 0.1135200904 | 0.9999902473 | 0.6457666523 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2573120650 |
| GSE13712_SHEAR | Down | -0.1409645589 |
| GSE13712_STATIC | Down | -0.1789130854 |
| GSE19018 | Up | 0.5724767401 |
| GSE19899_A1 | Down | -0.3262029568 |
| GSE19899_A2 | Up | 0.0494907454 |
| PubMed_21979375_A1 | Up | 0.6354085748 |
| PubMed_21979375_A2 | Down | -1.1746686976 |
| GSE35957 | Down | -0.3613396248 |
| GSE36640 | Down | -0.6681429512 |
| GSE54402 | Up | 0.4927295528 |
| GSE9593 | Down | -0.0506166905 |
| GSE43922 | Down | -0.1254928409 |
| GSE24585 | Up | 0.0531783935 |
| GSE37065 | Down | -0.1657657238 |
| GSE28863_A1 | Down | -0.1188185923 |
| GSE28863_A2 | Down | -0.2311016591 |
| GSE28863_A3 | Down | -0.2262235385 |
| GSE28863_A4 | Down | -0.0479892518 |
| GSE48662 | Up | 0.2341331098 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 1-Guanidinium-7-Aminoheptane | DB03639 | EXPT01555 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-186-5p | MIMAT0000456 | MIRT045190 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 9066781 | Deoxyhypusine synthase catalyzes the conversion of lysine to deoxyhypusine residue on the eukaryotic initiation factor 5A (elF-5A) precursor using spermidine as the substrate |
| 9066781 | In addition, an in vitro cross-labeling assay was developed for simultaneous measurement of the deoxyhypusine synthase activity and protein substrate (elF-5A precursor) amount |
| 9066781 | The striking difference in hypusine-forming activity between young and old cells was due to changes in both deoxyhypusine synthase activity and elF-5A precursor amount in IMR-90 cells during senescence |
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