HCSGD entry for CYB5R3
1. General information
| Official gene symbol | CYB5R3 |
|---|---|
| Entrez ID | 1727 |
| Gene full name | cytochrome b5 reductase 3 |
| Other gene symbols | B5R DIA1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004128 | Cytochrome-b5 reductase activity, acting on NAD(P)H | TAS | molecular_function |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005741 | Mitochondrial outer membrane | TAS | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005783 | Endoplasmic reticulum | IDA | cellular_component |
| GO:0005789 | Endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0005811 | Lipid particle | IDA | cellular_component |
| GO:0005833 | Hemoglobin complex | TAS | cellular_component |
| GO:0006695 | Cholesterol biosynthetic process | IEA | biological_process |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0008015 | Blood circulation | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016208 | AMP binding | IEA | molecular_function |
| GO:0016491 | Oxidoreductase activity | IEA | molecular_function |
| GO:0019852 | L-ascorbic acid metabolic process | TAS | biological_process |
| GO:0043531 | ADP binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0050660 | Flavin adenine dinucleotide binding | IEA | molecular_function |
| GO:0051287 | NAD binding | IEA | molecular_function |
| GO:0071949 | FAD binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1995376619 | 0.2164429961 | 0.8620882652 | 0.8958355031 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1519499143 |
| GSE13712_SHEAR | Down | -0.1715993983 |
| GSE13712_STATIC | Down | -0.1642618205 |
| GSE19018 | Up | 0.4783485861 |
| GSE19899_A1 | Down | -0.5618359878 |
| GSE19899_A2 | Up | 0.3726054834 |
| PubMed_21979375_A1 | Up | 0.5292352846 |
| PubMed_21979375_A2 | Down | -1.0420326038 |
| GSE35957 | Up | 0.1737381918 |
| GSE36640 | Up | 0.8980521801 |
| GSE54402 | Down | -0.2877640876 |
| GSE9593 | Up | 0.7216759125 |
| GSE43922 | Down | -0.2074971759 |
| GSE24585 | Up | 0.0410369871 |
| GSE37065 | Up | 0.0402906442 |
| GSE28863_A1 | Down | -0.0989099740 |
| GSE28863_A2 | Down | -0.2056932848 |
| GSE28863_A3 | Up | 0.1317125771 |
| GSE28863_A4 | Down | -0.0486328165 |
| GSE48662 | Up | 0.5614328844 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-98-5p | MIMAT0000096 | MIRT027454 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-744-5p | MIMAT0004945 | MIRT037551 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT042354 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-378a-3p | MIMAT0000732 | MIRT043904 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049610 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24450884 | AIMS: Membrane-bound CYB5R3 deficiency in humans causes recessive hereditary methaemoglobinaemia (RHM), an incurable disease that is characterized by severe neurological disorders |
| 24450884 | CYB5R3 encodes for NADH-dependent redox enzyme that contributes to metabolic homeostasis and stress protection; however, how it is involved in the neurological pathology of RHM remains unknown |
| 24450884 | Here, the role and transcriptional regulation of CYB5R3 was studied under nutritional and oxidative stress |
| 24450884 | INNOVATION: Our findings demonstrate that CYB5R3 contributes to regulate redox homeostasis, aerobic metabolism, and cellular senescence, suggesting that CYB5R3 might be a key effector of oxidative and nutritional stress pathways |
| 24450884 | These results unveil a potential mechanism of action by which CYB5R3 deficiency contributes to the pathophysiological underpinnings of neurological disorders in RHM patients |
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