HCSGD entry for DLX2
1. General information
| Official gene symbol | DLX2 |
|---|---|
| Entrez ID | 1746 |
| Gene full name | distal-less homeobox 2 |
| Other gene symbols | TES-1 TES1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0000976 | Transcription regulatory region sequence-specific DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | IEA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA | molecular_function |
| GO:0003727 | Single-stranded RNA binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0007420 | Brain development | TAS | biological_process |
| GO:0009954 | Proximal/distal pattern formation | IEA | biological_process |
| GO:0021544 | Subpallium development | IEA | biological_process |
| GO:0021766 | Hippocampus development | IEA | biological_process |
| GO:0021772 | Olfactory bulb development | IEA | biological_process |
| GO:0021882 | Regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment | IEA | biological_process |
| GO:0021893 | Cerebral cortex GABAergic interneuron fate commitment | IEA | biological_process |
| GO:0042475 | Odontogenesis of dentin-containing tooth | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0045746 | Negative regulation of Notch signaling pathway | IEA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0048701 | Embryonic cranial skeleton morphogenesis | IEA | biological_process |
| GO:0048715 | Negative regulation of oligodendrocyte differentiation | IEA | biological_process |
| GO:0048755 | Branching morphogenesis of a nerve | IEA | biological_process |
| GO:0051216 | Cartilage development | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2330946507 | 0.2500929524 | 0.9167691365 | 0.9601366103 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4479263133 |
| GSE13712_SHEAR | Up | 0.0877151236 |
| GSE13712_STATIC | Down | -0.0247937171 |
| GSE19018 | Down | -0.1778361170 |
| GSE19899_A1 | Up | 0.0667935882 |
| GSE19899_A2 | Down | -0.2827566684 |
| PubMed_21979375_A1 | Up | 0.3499221385 |
| PubMed_21979375_A2 | Down | -0.0059078092 |
| GSE35957 | Down | -0.7340960120 |
| GSE36640 | Down | -0.1207452111 |
| GSE54402 | Up | 0.3542946635 |
| GSE9593 | Down | -1.1815282687 |
| GSE43922 | Up | 0.0383926538 |
| GSE24585 | Up | 1.4516443863 |
| GSE37065 | Up | 0.0831579898 |
| GSE28863_A1 | Up | 0.0240717297 |
| GSE28863_A2 | Down | -0.0764252390 |
| GSE28863_A3 | Up | 0.1922158038 |
| GSE28863_A4 | Down | -0.0721325922 |
| GSE48662 | Up | 0.1141927567 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036105 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042820 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-331-3p | MIMAT0000760 | MIRT043264 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26833729 | A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling |
| 26833729 | Among the new genes now implicated in senescence, we identified DLX2, a homeobox transcription factor that has been shown to be required for tumor growth and metastasis and is associated with poor cancer prognosis |
| 26833729 | Growth analysis showed that DLX2 expression led to increased cellular replicative life span |
| 26833729 | Our data suggest that DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK (phosphatidylinositol 3-kinase-related kinase) family kinase, leading to reduced ATM-p53 signaling and senescence bypass |
| 26833729 | We also found that the overexpression of DLX2 exhibited a mutually exclusive relationship with p53 alterations in cancer patients |
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