HCSGD entry for DPYD

1. General information

Official gene symbolDPYD
Entrez ID1806
Gene full namedihydropyrimidine dehydrogenase
Other gene symbolsDHP DHPDHASE DPD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004158Dihydroorotate oxidase activityIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006145Purine nucleobase catabolic processIMPbiological_process
GO:0006206Pyrimidine nucleobase metabolic processTASbiological_process
GO:0006208Pyrimidine nucleobase catabolic processIMP ISSbiological_process
GO:0006210Thymine catabolic processIDAbiological_process
GO:0006212Uracil catabolic processIDAbiological_process
GO:0006214Thymidine catabolic processIDAbiological_process
GO:0006222UMP biosynthetic processIEAbiological_process
GO:0017113Dihydropyrimidine dehydrogenase (NADP+) activityIDA IMP ISS TASmolecular_function
GO:0019483Beta-alanine biosynthetic processIEAbiological_process
GO:0042803Protein homodimerization activityIDA ISSmolecular_function
GO:0044281Small molecule metabolic processTASbiological_process
GO:0046135Pyrimidine nucleoside catabolic processTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050660Flavin adenine dinucleotide bindingISSmolecular_function
GO:0050661NADP bindingISSmolecular_function
GO:0051536Iron-sulfur cluster bindingIEAmolecular_function
GO:00515394 iron, 4 sulfur cluster bindingIEAmolecular_function
GO:0055086Nucleobase-containing small molecule metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88432103640.01967560120.99999024730.2731442511

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2616364950
GSE13712_SHEARDown-0.0101330375
GSE13712_STATICUp0.0311395617
GSE19018Down-0.0242433940
GSE19899_A1Down-0.4068442803
GSE19899_A2Down-0.6512620219
PubMed_21979375_A1Down-2.0635859080
PubMed_21979375_A2Down-0.9850470236
GSE35957Up0.2215574350
GSE36640Down-0.3898064237
GSE54402Down-0.7020792488
GSE9593Up0.0469174980
GSE43922Down-0.7213687721
GSE24585Up0.3128975745
GSE37065Down-0.1106803996
GSE28863_A1Up0.4337881271
GSE28863_A2Up0.7842128670
GSE28863_A3Down-0.2650312749
GSE28863_A4Down-0.1656721133
GSE48662Down-0.1810105224

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

(5s)-5-Iododihydro-2,4(1h,3h)-PyrimidinedioneDB02303 EXPT01839
Nadph Dihydro-Nicotinamide-Adenine-DinucleotidephosphateDB02338 EXPT02321
6-CarboxymethyluracilDB03048 EXPT03164
Riboflavin MonophosphateDB03247 EXPT01458
UracilDB03419 EXPT03201
EniluracilDB03516 EXPT03299
5-IodouracilDB03554 EXPT01946

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT022744MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.