HCSGD entry for DR1
1. General information
| Official gene symbol | DR1 |
|---|---|
| Entrez ID | 1810 |
| Gene full name | down-regulator of transcription 1, TBP-binding (negative cofactor 2) |
| Other gene symbols | NC2 NC2-BETA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0003714 | Transcription corepressor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008134 | Transcription factor binding | TAS | molecular_function |
| GO:0017025 | TBP-class protein binding | IDA | molecular_function |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0043966 | Histone H3 acetylation | IDA | biological_process |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3260155997 | 0.4794809696 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2786875499 |
| GSE13712_SHEAR | Up | 0.2716833033 |
| GSE13712_STATIC | Up | 0.3337777569 |
| GSE19018 | Down | -0.1881960771 |
| GSE19899_A1 | Up | 0.2894076979 |
| GSE19899_A2 | Up | 0.3524658920 |
| PubMed_21979375_A1 | Up | 0.4060980682 |
| PubMed_21979375_A2 | Up | 0.3572204158 |
| GSE35957 | Down | -0.2439602196 |
| GSE36640 | Down | -0.0314528513 |
| GSE54402 | Up | 0.1002983752 |
| GSE9593 | Down | -0.2810510767 |
| GSE43922 | Up | 0.0412488015 |
| GSE24585 | Down | -0.1266528147 |
| GSE37065 | Down | -0.1537040052 |
| GSE28863_A1 | Down | -0.1736975529 |
| GSE28863_A2 | Up | 0.3978162218 |
| GSE28863_A3 | Down | -0.8246601228 |
| GSE28863_A4 | Down | -0.1559182205 |
| GSE48662 | Down | -0.2373574216 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT020005 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020974 | Proteomics | Functional MTI (Weak) | 20584899 |
| hsa-miR-320a | MIMAT0000510 | MIRT044688 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
