HCSGD entry for SLC26A3

1. General information

Official gene symbolSLC26A3
Entrez ID1811
Gene full namesolute carrier family 26, member 3
Other gene symbolsCLD DRA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003712Transcription cofactor activityTASmolecular_function
GO:0005215Transporter activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006355Regulation of transcription, DNA-templatedTASbiological_process
GO:0006811Ion transportTASbiological_process
GO:0006820Anion transportTASbiological_process
GO:0007588ExcretionTASbiological_process
GO:0008271Secondary active sulfate transmembrane transporter activityIEAmolecular_function
GO:0015106Bicarbonate transmembrane transporter activityIEA ISSmolecular_function
GO:0015108Chloride transmembrane transporter activityIEA ISSmolecular_function
GO:0015301Anion:anion antiporter activityIEAmolecular_function
GO:0016020MembraneISScellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016324Apical plasma membraneIEAcellular_component
GO:0031526Brush border membraneIEAcellular_component
GO:0034220Ion transmembrane transportISSbiological_process
GO:0048240Sperm capacitationIEA ISSbiological_process
GO:0051454Intracellular pH elevationIEA ISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060081Membrane hyperpolarizationIEA ISSbiological_process
GO:0071320Cellular response to cAMPIEA ISSbiological_process
GO:0097225Sperm midpieceIEA ISScellular_component
GO:1902476Chloride transmembrane transportISSbiological_process
GO:2001141Regulation of RNA biosynthetic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.60660500740.91218165720.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0512221738
GSE13712_SHEARDown-0.1361639810
GSE13712_STATICDown-0.1389917611
GSE19018Up0.1249434219
GSE19899_A1Up0.1557920193
GSE19899_A2Down-0.0295098793
PubMed_21979375_A1Down-0.0677933865
PubMed_21979375_A2Up0.1424986099
GSE35957Up0.0316375125
GSE36640Down-0.0832465868
GSE54402Up0.0563177898
GSE9593Up0.0573110459
GSE43922Up0.0191538524
GSE24585Up0.3064445994
GSE37065Up0.0568609379
GSE28863_A1Up0.0377835756
GSE28863_A2Down-0.0578243244
GSE28863_A3Up0.1733929715
GSE28863_A4Up0.0307493361
GSE48662Up0.0061629578

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016734MicroarrayFunctional MTI (Weak)18185580
hsa-miR-7-5pMIMAT0000252MIRT025629MicroarrayFunctional MTI (Weak)17612493
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

19937729Enhanced oxidative stress is a common feature of liver diseases and contributes to chronic liver disease (CLD) progression by inducing fibrogenesis during liver regeneration
18845559Two of these, SLC26a3/DRA (downregulated in adenoma) and Na+/H+ exchanger 2 (NHE2), were not previously known to be elevated in BE; however, we confirmed their elevation in BE tissue samples
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