HCSGD entry for DSC3
1. General information
| Official gene symbol | DSC3 |
|---|---|
| Entrez ID | 1825 |
| Gene full name | desmocollin 3 |
| Other gene symbols | CDHF3 DSC DSC1 DSC2 DSC4 HT-CP |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0005911 | Cell-cell junction | TAS | cellular_component |
| GO:0007155 | Cell adhesion | TAS | biological_process |
| GO:0007156 | Homophilic cell adhesion | IEA | biological_process |
| GO:0016020 | Membrane | IEA TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0030057 | Desmosome | IEA | cellular_component |
| GO:0045295 | Gamma-catenin binding | IPI | molecular_function |
| GO:0050821 | Protein stabilization | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9524639375 | 0.2534851563 | 0.9999902473 | 0.9663454282 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0770437496 |
| GSE13712_SHEAR | Down | -0.0914924426 |
| GSE13712_STATIC | Down | -0.1122534962 |
| GSE19018 | Down | -0.0032538762 |
| GSE19899_A1 | Up | 0.0377070843 |
| GSE19899_A2 | Down | -0.0038088662 |
| PubMed_21979375_A1 | Down | -0.0148667768 |
| PubMed_21979375_A2 | Down | -0.0617709971 |
| GSE35957 | Up | 0.0080558727 |
| GSE36640 | Down | -0.3446208148 |
| GSE54402 | Down | -0.2514186828 |
| GSE9593 | Up | 0.0570590121 |
| GSE43922 | Up | 0.1854197417 |
| GSE24585 | Down | -0.6373448014 |
| GSE37065 | Up | 0.1347880616 |
| GSE28863_A1 | Down | -0.1357676472 |
| GSE28863_A2 | Up | 0.0175942986 |
| GSE28863_A3 | Up | 0.0317307716 |
| GSE28863_A4 | Down | -0.0604670336 |
| GSE48662 | Up | 0.0274410244 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-33a-5p | MIMAT0000091 | MIRT028229 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028311 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT051723 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052624 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 17266044 | Array CGH revealed genomic changes resembling those of ovarian carcinomas, such as amplicons at 3q and 20q, and deletions at 4q and 18, associated with underexpressed annexin A10, N-cadherin, desmocollin 3 and PAI-2, which have been reported as tumor suppressors |
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