HCSGD entry for DVL2
1. General information
| Official gene symbol | DVL2 |
|---|---|
| Entrez ID | 1856 |
| Gene full name | dishevelled segment polarity protein 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001843 | Neural tube closure | ISS | biological_process |
| GO:0001934 | Positive regulation of protein phosphorylation | IMP | biological_process |
| GO:0003007 | Heart morphogenesis | IBA | biological_process |
| GO:0003151 | Outflow tract morphogenesis | ISS | biological_process |
| GO:0004871 | Signal transducer activity | IEA | molecular_function |
| GO:0005109 | Frizzled binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005634 | Nucleus | ISS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005886 | Plasma membrane | IBA | cellular_component |
| GO:0005938 | Cell cortex | IBA | cellular_component |
| GO:0006366 | Transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0007379 | Segment specification | ISS | biological_process |
| GO:0007507 | Heart development | ISS | biological_process |
| GO:0016055 | Wnt signaling pathway | IGI | biological_process |
| GO:0019904 | Protein domain specific binding | IEA | molecular_function |
| GO:0021535 | Cell migration in hindbrain | IBA | biological_process |
| GO:0022007 | Convergent extension involved in neural plate elongation | IEA | biological_process |
| GO:0030136 | Clathrin-coated vesicle | IBA | cellular_component |
| GO:0031410 | Cytoplasmic vesicle | IDA | cellular_component |
| GO:0034613 | Cellular protein localization | IEA | biological_process |
| GO:0035329 | Hippo signaling | TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IEA | biological_process |
| GO:0035567 | Non-canonical Wnt signaling pathway | IMP | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0043507 | Positive regulation of JUN kinase activity | IDA IMP | biological_process |
| GO:0043621 | Protein self-association | IEA | molecular_function |
| GO:0044340 | Canonical Wnt signaling pathway involved in regulation of cell proliferation | IDA | biological_process |
| GO:0045177 | Apical part of cell | IBA | cellular_component |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IDA | biological_process |
| GO:0060026 | Convergent extension | IBA | biological_process |
| GO:0060070 | Canonical Wnt signaling pathway | IDA | biological_process |
| GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | IDA | biological_process |
| GO:0061098 | Positive regulation of protein tyrosine kinase activity | IEA | biological_process |
| GO:0090103 | Cochlea morphogenesis | IBA | biological_process |
| GO:0090179 | Planar cell polarity pathway involved in neural tube closure | IBA | biological_process |
| GO:0090263 | Positive regulation of canonical Wnt signaling pathway | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9840633069 | 0.0208868812 | 0.9999902473 | 0.2793514228 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0360198757 |
| GSE13712_SHEAR | Down | -0.4941370003 |
| GSE13712_STATIC | Down | -0.2499766829 |
| GSE19018 | Down | -0.0701782352 |
| GSE19899_A1 | Down | -0.4120024178 |
| GSE19899_A2 | Down | -0.6249514479 |
| PubMed_21979375_A1 | Down | -1.1209558535 |
| PubMed_21979375_A2 | Down | -0.5087859613 |
| GSE35957 | Down | -0.4352069447 |
| GSE36640 | Down | -0.4204177388 |
| GSE54402 | Down | -0.1687890661 |
| GSE9593 | Down | -0.2281605619 |
| GSE43922 | Down | -0.4121437093 |
| GSE24585 | Up | 0.4000519721 |
| GSE37065 | Down | -0.0312147737 |
| GSE28863_A1 | Up | 0.1367535833 |
| GSE28863_A2 | Down | -0.1419610523 |
| GSE28863_A3 | Down | -0.3184852572 |
| GSE28863_A4 | Down | -0.1693124798 |
| GSE48662 | Up | 0.0068402211 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002652 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002652 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT004684 | Luciferase reporter assay | Functional MTI | 19478946 |
| hsa-miR-221-3p | MIMAT0000278 | MIRT024149 | Western blot;qRT-PCR | Functional MTI | 21487968 |
| hsa-miR-484 | MIMAT0002174 | MIRT041680 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
