HCSGD entry for EDA

1. General information

Official gene symbolEDA
Entrez ID1896
Gene full nameectodysplasin A
Other gene symbolsECTD1 ED1 ED1-A1 ED1-A2 EDA-A1 EDA-A2 EDA1 EDA2 HED HED1 ODT1 STHAGX1 XHED XLHED
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005102Receptor bindingIDAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005581CollagenIEAcellular_component
GO:0005789Endoplasmic reticulum membraneIEAcellular_component
GO:0005856CytoskeletonTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIEAcellular_component
GO:0006955Immune responseIEAbiological_process
GO:0007160Cell-matrix adhesionIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007398Ectoderm developmentTASbiological_process
GO:0010467Gene expressionIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016021Integral component of membraneTAScellular_component
GO:0030154Cell differentiationIEAbiological_process
GO:0042346Positive regulation of NF-kappaB import into nucleusIEAbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0043473PigmentationIEAbiological_process
GO:0045177Apical part of cellIEAcellular_component
GO:0051092Positive regulation of NF-kappaB transcription factor activityIDAbiological_process
GO:0060662Salivary gland cavitationIEAbiological_process
GO:0060789Hair follicle placode formationIEAbiological_process
GO:0061153Trachea gland developmentIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92995041600.56687847730.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0674754089
GSE13712_SHEARDown-0.0363171112
GSE13712_STATICUp0.0142879892
GSE19018Up0.0062757225
GSE19899_A1Down-0.0245554040
GSE19899_A2Down-0.0327363089
PubMed_21979375_A1Down-0.1255925983
PubMed_21979375_A2Up0.1234578828
GSE35957Down-0.0538252654
GSE36640Up0.0090916536
GSE54402Up0.0652122639
GSE9593Down-0.0458717499
GSE43922Up0.0153025166
GSE24585Down-0.2246470603
GSE37065Down-0.1097376338
GSE28863_A1Down-0.1725067153
GSE28863_A2Down-0.2160998005
GSE28863_A3Up0.1734434720
GSE28863_A4Up0.0456282161
GSE48662Up0.0429085127

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-let-7f-5pMIMAT0000067MIRT051411CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

10212139Pre-fibronectin mRNA is subject to alternative splicing at three sites, EDA, EDB and IIICS
10212139Reverse transcription-polymerase chain reaction analyses showed cells that produced a single form of mRNA at each one of these sites as well as cells that produced multiple forms at a given site: for example, some cells produced either the EDA(+) or EDA(-) form of the mRNA and other cells produced both forms
10212139About 80% of the cells produced both (+) and (-) forms of the mRNA at the EDA and EDB sites, and the remaining cells contained either the (+) or (-) form
1713586Whereas fibronectin mRNAs from adult rat tissues were found to range from 0 to 25% ED-A+ and from 0 to 10% ED-B+, fibronectin mRNAs from cultured cell lines were found to be approximately 50-60% ED-A+ and 15-25% ED-B+
1713586We demonstrate that serum deprivation; placement of cells into primary culture; and growth factors such as transforming growth factor beta 1, retinoic acid, and 1,25-dihydroxyvitamin D3 can all change the alternative splicing of fibronectin pre-mRNA in the ED-A, ED-B, and type III connecting sequence exons
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