HCSGD entry for EFNA1

1. General information

Official gene symbolEFNA1
Entrez ID1942
Gene full nameephrin-A1
Other gene symbolsB61 ECKLG EFL1 EPLG1 LERK-1 LERK1 TNFAIP4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterISSbiological_process
GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001525AngiogenesisIEAbiological_process
GO:0003180Aortic valve morphogenesisISSbiological_process
GO:0003183Mitral valve morphogenesisISSbiological_process
GO:0003199Endocardial cushion to mesenchymal transition involved in heart valve formationISSbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007267Cell-cell signalingTASbiological_process
GO:0010719Negative regulation of epithelial to mesenchymal transitionISSbiological_process
GO:0014028Notochord formationIEAbiological_process
GO:0016477Cell migrationIDAbiological_process
GO:0030182Neuron differentiationIEAbiological_process
GO:0033628Regulation of cell adhesion mediated by integrinIDAbiological_process
GO:0034446Substrate adhesion-dependent cell spreadingIDAbiological_process
GO:0043535Regulation of blood vessel endothelial cell migrationIEAbiological_process
GO:0045765Regulation of angiogenesisIEAbiological_process
GO:0046658Anchored component of plasma membraneIEAcellular_component
GO:0046875Ephrin receptor bindingIPImolecular_function
GO:0048013Ephrin receptor signaling pathwayIDAbiological_process
GO:0050730Regulation of peptidyl-tyrosine phosphorylationISSbiological_process
GO:0050731Positive regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050770Regulation of axonogenesisIEAbiological_process
GO:0061002Negative regulation of dendritic spine morphogenesisISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.68552459630.25051137110.99999024730.9609669338

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0292365907
GSE13712_SHEARDown-0.5943032629
GSE13712_STATICDown-0.6055230942
GSE19018Up0.0548341052
GSE19899_A1Up0.0573732079
GSE19899_A2Up0.2088002255
PubMed_21979375_A1Down-0.0311938196
PubMed_21979375_A2Up0.2565262159
GSE35957Down-0.0497076505
GSE36640Down-0.0090962002
GSE54402Down-0.3238931013
GSE9593Down-0.8788906422
GSE43922Up0.0223392252
GSE24585Up0.6060769582
GSE37065Down-0.1303334793
GSE28863_A1Down-0.0229412746
GSE28863_A2Up0.1000166895
GSE28863_A3Up0.1519791510
GSE28863_A4Up0.0277842426
GSE48662Down-0.0168701296

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-218-5pMIMAT0000275MIRT001058qRT-PCR//Western blotNon-Functional MTI17998940
hsa-miR-335-5pMIMAT0000765MIRT016724MicroarrayFunctional MTI (Weak)18185580
hsa-miR-9-5pMIMAT0000441MIRT021322MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT022145MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24141256In the young heart, signaling by the guidance receptor EphA2 in response to the ephrin A1 ligand promotes hCPC motility and improves cardiac recovery after infarction
24141256Based on the ability of phenotypically young hCPCs to respond efficiently to ephrin A1, we developed a novel methodology for the prospective isolation of live hCPCs with preserved migratory capacity and growth reserve
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