HCSGD entry for EIF2S1

1. General information

Official gene symbolEIF2S1
Entrez ID1965
Gene full nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
Other gene symbolsEIF-2 EIF-2A EIF-2alpha EIF2 EIF2A
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003743Translation initiation factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0005844PolysomeTAScellular_component
GO:0005850Eukaryotic translation initiation factor 2 complexIEAcellular_component
GO:0005851Eukaryotic translation initiation factor 2B complexIDAcellular_component
GO:0006412TranslationTASbiological_process
GO:0006413Translational initiationTASbiological_process
GO:0006987Activation of signaling protein activity involved in unfolded protein responseTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0010494Cytoplasmic stress granuleIEA ISScellular_component
GO:0030968Endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0043022Ribosome bindingIDAmolecular_function
GO:0043558Regulation of translational initiation in response to stressIEAbiological_process
GO:0044267Cellular protein metabolic processTASbiological_process
GO:0046777Protein autophosphorylationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.31695017670.55623044340.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1838637701
GSE13712_SHEARDown-0.1986115869
GSE13712_STATICDown-0.0945824886
GSE19018Down-0.6986566333
GSE19899_A1Up0.3162482930
GSE19899_A2Up0.1706802813
PubMed_21979375_A1Up0.1703118359
PubMed_21979375_A2Up0.3857173524
GSE35957Down-0.1069651595
GSE36640Down-0.0906042033
GSE54402Up0.2057760067
GSE9593Down-0.1203757893
GSE43922Up0.2203427808
GSE24585Down-0.2046443947
GSE37065Up0.0583050610
GSE28863_A1Down-0.0595046340
GSE28863_A2Up0.1734312080
GSE28863_A3Down-0.4556874388
GSE28863_A4Up0.1606978538
GSE48662Up0.0450641057

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT004813Quantitative proteomic approachFunctional MTI (Weak)19253296
hsa-miR-375MIMAT0000728MIRT019778MicroarrayFunctional MTI (Weak)20215506
hsa-miR-192-5pMIMAT0000222MIRT026383SequencingFunctional MTI (Weak)20371350
hsa-miR-222-3pMIMAT0000279MIRT046815CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22788682ER stress was detected by assays for glucose-regulated protein 78 (GRP78), CCAAT/enhancer-binding protein homologous protein (CHOP), and growth arrest and DNA damage-inducible protein 34 (GADD34) mRNA, and transient phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha)
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