HCSGD entry for CRTC2
1. General information
| Official gene symbol | CRTC2 |
|---|---|
| Entrez ID | 200186 |
| Gene full name | CREB regulated transcription coactivator 2 |
| Other gene symbols | TORC-2 TORC2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IEA ISS | cellular_component |
| GO:0006094 | Gluconeogenesis | ISS | biological_process |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0008140 | CAMP response element binding protein binding | IEA | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0032793 | Positive regulation of CREB transcription factor activity | IEA ISS | biological_process |
| GO:0042593 | Glucose homeostasis | ISS | biological_process |
| GO:0051289 | Protein homotetramerization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0992068918 | 0.9354844421 | 0.6579522516 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0397969562 |
| GSE13712_SHEAR | Down | -0.3932714637 |
| GSE13712_STATIC | Up | 0.0375452997 |
| GSE19018 | Up | 0.0749511251 |
| GSE19899_A1 | Down | -0.0006133493 |
| GSE19899_A2 | Up | 0.2729382555 |
| PubMed_21979375_A1 | Up | 0.5665897861 |
| PubMed_21979375_A2 | Up | 1.0548440552 |
| GSE35957 | Down | -0.1420927340 |
| GSE36640 | Up | 0.0882155829 |
| GSE54402 | Up | 0.3578909354 |
| GSE9593 | Up | 0.0287481151 |
| GSE43922 | Up | 0.3672835210 |
| GSE24585 | Up | 0.1644782477 |
| GSE37065 | Up | 0.0668619042 |
| GSE28863_A1 | Down | -0.0079973321 |
| GSE28863_A2 | Up | 0.3761238029 |
| GSE28863_A3 | Up | 0.2408845464 |
| GSE28863_A4 | Down | -0.1212113549 |
| GSE48662 | Down | -0.1015285588 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049460 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26851731 | Our findings suggest that combined inhibition of both mTORC1 and mTORC2 may provide a promising strategy to reverse the development of senescence-associated features in near-senescent cells |
| 25697003 | After the suppression of MEK/ERK, activity of mTORC1 increased as well as complex mTORC2 |
| 22627671 | Depletion of TORC2 fails to affect the course of replicative or RAS-induced senescence |
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