HCSGD entry for APLF
1. General information
| Official gene symbol | APLF |
|---|---|
| Entrez ID | 200558 |
| Gene full name | aprataxin and PNKP like factor |
| Other gene symbols | APFL C2orf13 PALF Xip1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000012 | Single strand break repair | IMP | biological_process |
| GO:0000166 | Nucleotide binding | IDA | molecular_function |
| GO:0000737 | DNA catabolic process, endonucleolytic | IDA | biological_process |
| GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity | IDA | molecular_function |
| GO:0004520 | Endodeoxyribonuclease activity | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006302 | Double-strand break repair | IMP | biological_process |
| GO:0006308 | DNA catabolic process | IDA | biological_process |
| GO:0006974 | Cellular response to DNA damage stimulus | IDA | biological_process |
| GO:0008408 | 3'-5' exonuclease activity | IDA | molecular_function |
| GO:0035861 | Site of double-strand break | IDA | cellular_component |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0051106 | Positive regulation of DNA ligation | IGI | biological_process |
| GO:0090305 | Nucleic acid phosphodiester bond hydrolysis | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6474034573 | 0.6061486000 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1063938957 |
| GSE13712_SHEAR | Down | -0.0376438689 |
| GSE13712_STATIC | Up | 0.0218639215 |
| GSE19018 | Up | 0.3843765539 |
| GSE19899_A1 | Up | 0.1368295972 |
| GSE19899_A2 | Up | 0.4508687403 |
| PubMed_21979375_A1 | Up | 0.3904555147 |
| PubMed_21979375_A2 | Down | -0.0269908020 |
| GSE35957 | Down | -0.1392853399 |
| GSE36640 | Down | -0.2013887183 |
| GSE54402 | Up | 0.1495162150 |
| GSE9593 | Up | 0.0014930330 |
| GSE43922 | Up | 0.0574177319 |
| GSE24585 | Up | 0.0282666807 |
| GSE37065 | Down | -0.0623225324 |
| GSE28863_A1 | Down | -0.2483790309 |
| GSE28863_A2 | Up | 0.1616269625 |
| GSE28863_A3 | Down | -0.3021034471 |
| GSE28863_A4 | Down | -0.2266334318 |
| GSE48662 | Down | -0.0723474486 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
