HCSGD entry for ELN


1. General information

Official gene symbolELN
Entrez ID2006
Gene full nameelastin
Other gene symbolsSVAS WBS WS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001974Blood vessel remodelingIEAbiological_process
GO:0005201Extracellular matrix structural constituentIEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005578Proteinaceous extracellular matrixIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0007519Skeletal muscle tissue developmentIEAbiological_process
GO:0007585Respiratory gaseous exchangeTASbiological_process
GO:0008015Blood circulationTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0009887Organ morphogenesisTASbiological_process
GO:0030023Extracellular matrix constituent conferring elasticityIEAmolecular_function
GO:0030198Extracellular matrix organizationTASbiological_process
GO:0030833Regulation of actin filament polymerizationIEAbiological_process
GO:0043149Stress fiber assemblyIEAbiological_process
GO:0050840Extracellular matrix bindingIEAmolecular_function
GO:0071953Elastic fiberIEAcellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.83795306410.00647243270.99999024730.1636646226

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0465103962
GSE13712_SHEARDown-0.7548060200
GSE13712_STATICDown-0.1196365141
GSE19018Down-0.9803966125
GSE19899_A1Down-0.0492889859
GSE19899_A2Down-0.0490895228
PubMed_21979375_A1Down-0.4160108152
PubMed_21979375_A2Down-0.8929629653
GSE35957Up1.7307197712
GSE36640Down-0.2351266010
GSE54402Down-0.3404841506
GSE9593Down-0.7168030341
GSE43922Up0.0508050541
GSE24585Up0.0099208627
GSE37065Down-0.5206415108
GSE28863_A1Down-0.4562341383
GSE28863_A2Down-0.7548216451
GSE28863_A3Up0.5429424906
GSE28863_A4Down-0.3875572794
GSE48662Up0.4712039523

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

RofecoxibDB00533 APRD00151

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

22358238The expression levels of ELN, COL1A1, MMP1, CCND1, RB1, and IL6 genes were determined using the quantitative real-time polymerase chain reaction
19682489An enhanced formation of extracellular filaments, consisting of elastin-like structures, in senescent post-selection HMEC populations was paralleled by a significantly increased expression of its precursor protein tropoelastin and matched with a markedly elevated activity of the cross-linking enzyme family of lysyl oxidases (LOX)
19682489RNAi experiments revealed both the ECM metalloproteinase MMP-7 and the growth factor HB-EGF as potential effectors of an increased tropoelastin expression
19682489Moreover, co-localization of MMP-7 and HB-EGF as well as a concomittant downstream signaling via Fra-1 indicated a possible association between the reduced MMP-7 enzyme activity and an impaired HB-EGF processing, resulting in an enhanced tropoelastin synthesis during senescence of HMEC
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