HCSGD entry for ELN
1. General information
Official gene symbol | ELN |
---|---|
Entrez ID | 2006 |
Gene full name | elastin |
Other gene symbols | SVAS WBS WS |
Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network

This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
---|---|---|---|
GO:0001974 | Blood vessel remodeling | IEA | biological_process |
GO:0005201 | Extracellular matrix structural constituent | IEA TAS | molecular_function |
GO:0005515 | Protein binding | IPI | molecular_function |
GO:0005576 | Extracellular region | TAS | cellular_component |
GO:0005578 | Proteinaceous extracellular matrix | IEA | cellular_component |
GO:0005739 | Mitochondrion | IEA | cellular_component |
GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
GO:0007585 | Respiratory gaseous exchange | TAS | biological_process |
GO:0008015 | Blood circulation | TAS | biological_process |
GO:0008283 | Cell proliferation | TAS | biological_process |
GO:0009887 | Organ morphogenesis | TAS | biological_process |
GO:0030023 | Extracellular matrix constituent conferring elasticity | IEA | molecular_function |
GO:0030198 | Extracellular matrix organization | TAS | biological_process |
GO:0030833 | Regulation of actin filament polymerization | IEA | biological_process |
GO:0043149 | Stress fiber assembly | IEA | biological_process |
GO:0050840 | Extracellular matrix binding | IEA | molecular_function |
GO:0071953 | Elastic fiber | IEA | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
p-value up | p-value down | FDR up | FDR down |
---|---|---|---|
0.8379530641 | 0.0064724327 | 0.9999902473 | 0.1636646226 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
Data source | Up or down | Log fold change |
---|---|---|
GSE11954 | Down | -0.0465103962 |
GSE13712_SHEAR | Down | -0.7548060200 |
GSE13712_STATIC | Down | -0.1196365141 |
GSE19018 | Down | -0.9803966125 |
GSE19899_A1 | Down | -0.0492889859 |
GSE19899_A2 | Down | -0.0490895228 |
PubMed_21979375_A1 | Down | -0.4160108152 |
PubMed_21979375_A2 | Down | -0.8929629653 |
GSE35957 | Up | 1.7307197712 |
GSE36640 | Down | -0.2351266010 |
GSE54402 | Down | -0.3404841506 |
GSE9593 | Down | -0.7168030341 |
GSE43922 | Up | 0.0508050541 |
GSE24585 | Up | 0.0099208627 |
GSE37065 | Down | -0.5206415108 |
GSE28863_A1 | Down | -0.4562341383 |
GSE28863_A2 | Down | -0.7548216451 |
GSE28863_A3 | Up | 0.5429424906 |
GSE28863_A4 | Down | -0.3875572794 |
GSE48662 | Up | 0.4712039523 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
---|---|---|
Rofecoxib | DB00533 | APRD00151 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
---|---|
22358238 | The expression levels of ELN, COL1A1, MMP1, CCND1, RB1, and IL6 genes were determined using the quantitative real-time polymerase chain reaction |
19682489 | An enhanced formation of extracellular filaments, consisting of elastin-like structures, in senescent post-selection HMEC populations was paralleled by a significantly increased expression of its precursor protein tropoelastin and matched with a markedly elevated activity of the cross-linking enzyme family of lysyl oxidases (LOX) |
19682489 | RNAi experiments revealed both the ECM metalloproteinase MMP-7 and the growth factor HB-EGF as potential effectors of an increased tropoelastin expression |
19682489 | Moreover, co-localization of MMP-7 and HB-EGF as well as a concomittant downstream signaling via Fra-1 indicated a possible association between the reduced MMP-7 enzyme activity and an impaired HB-EGF processing, resulting in an enhanced tropoelastin synthesis during senescence of HMEC |
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