HCSGD entry for DHFRL1
1. General information
| Official gene symbol | DHFRL1 |
|---|---|
| Entrez ID | 200895 |
| Gene full name | dihydrofolate reductase-like 1 |
| Other gene symbols | DHFRP4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003729 | MRNA binding | IDA | molecular_function |
| GO:0004146 | Dihydrofolate reductase activity | IEA IMP | molecular_function |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IMP | cellular_component |
| GO:0005759 | Mitochondrial matrix | IMP | cellular_component |
| GO:0006545 | Glycine biosynthetic process | IEA | biological_process |
| GO:0006730 | One-carbon metabolic process | IEA | biological_process |
| GO:0009165 | Nucleotide biosynthetic process | IEA | biological_process |
| GO:0046105 | Thymidine biosynthetic process | IDA | biological_process |
| GO:0046653 | Tetrahydrofolate metabolic process | IDA | biological_process |
| GO:0046654 | Tetrahydrofolate biosynthetic process | IEA | biological_process |
| GO:0050661 | NADP binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8319905627 | 0.0442153908 | 0.9999902473 | 0.3954445464 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0464731575 |
| GSE13712_SHEAR | Down | -0.0845516640 |
| GSE13712_STATIC | Up | 0.2852558818 |
| GSE19018 | Down | -0.5645231972 |
| GSE19899_A1 | Down | -0.3117232401 |
| GSE19899_A2 | Down | -0.6510882773 |
| PubMed_21979375_A1 | Down | -2.1555952282 |
| PubMed_21979375_A2 | Down | -0.9851121916 |
| GSE35957 | Down | -0.1995041567 |
| GSE36640 | Down | -0.1079241601 |
| GSE54402 | Down | -0.3548436186 |
| GSE9593 | Up | 0.0849864687 |
| GSE43922 | Up | 0.0414571617 |
| GSE24585 | Up | 0.1695227494 |
| GSE37065 | Down | -0.0522959195 |
| GSE28863_A1 | Up | 0.6134963342 |
| GSE28863_A2 | Up | 0.2379752102 |
| GSE28863_A3 | Down | -0.2227363737 |
| GSE28863_A4 | Down | -0.1991588830 |
| GSE48662 | Up | 0.1324633157 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| 5-Chloryl-2,4,6-Quinazolinetriamine | DB01929 | EXPT00950 |
| 5-[4-Tert-Butylphenylsulfanyl]-2,4-Quinazolinediamine | DB01958 | EXPT03101 |
| 5-(4-Morpholin-4-Yl-Phenylsulfanyl)-2,4-Quinazolinediamine | DB02001 | EXPT03102 |
| 5-(4-Methoxyphenoxy)-2,4-Quinazolinediamine | DB02402 | EXPT02228 |
| 5-Phenylsulfanyl-2,4-Quinazolinediamine | DB04163 | EXPT03099 |
| 5-[(4-Methylphenyl)Sulfanyl]-2,4-Quinazolinediamine | DB04306 | EXPT03100 |
| 7-(1-ETHYL-PROPYL)-7H-PYRROLO-[3,2-F]QUINAZOLINE-1,3-DIAMINE | DB07862 | - |
| 7-[2-METHOXY-1-(METHOXYMETHYL)ETHYL]-7H-PYRROLO[3,2-F] QUINAZOLINE-1,3-DIAMINE | DB08203 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-215-5p | MIMAT0000272 | MIRT024349 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026377 | Microarray | Functional MTI (Weak) | 19074876 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
