HCSGD entry for MARK2
1. General information
| Official gene symbol | MARK2 |
|---|---|
| Entrez ID | 2011 |
| Gene full name | MAP/microtubule affinity-regulating kinase 2 |
| Other gene symbols | EMK-1 EMK1 PAR-1 Par-1b Par1b |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000287 | Magnesium ion binding | IDA | molecular_function |
| GO:0001764 | Neuron migration | IEA ISS | biological_process |
| GO:0004674 | Protein serine/threonine kinase activity | IDA IEA NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IDA IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | IDA NAS | biological_process |
| GO:0008289 | Lipid binding | IEA | molecular_function |
| GO:0010976 | Positive regulation of neuron projection development | IDA | biological_process |
| GO:0016020 | Membrane | IEA IMP | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016301 | Kinase activity | IEA | molecular_function |
| GO:0030010 | Establishment of cell polarity | IDA TAS | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0045180 | Basal cortex | IEA | cellular_component |
| GO:0045197 | Establishment or maintenance of epithelial cell apical/basal polarity | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA ISS | biological_process |
| GO:0050321 | Tau-protein kinase activity | IEA ISS | molecular_function |
| GO:0050770 | Regulation of axonogenesis | IMP | biological_process |
| GO:0051493 | Regulation of cytoskeleton organization | IEA ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0965446032 | 0.9129764181 | 0.6491022222 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0162451438 |
| GSE13712_SHEAR | Up | 0.1918267533 |
| GSE13712_STATIC | Up | 0.1862573741 |
| GSE19018 | Up | 0.1774063222 |
| GSE19899_A1 | Down | -0.1668793473 |
| GSE19899_A2 | Up | 0.7714095028 |
| PubMed_21979375_A1 | Up | 0.4242647845 |
| PubMed_21979375_A2 | Up | 0.3771315769 |
| GSE35957 | Down | -0.1208040087 |
| GSE36640 | Down | -0.0078036874 |
| GSE54402 | Up | 0.3705327166 |
| GSE9593 | Up | 0.2222305401 |
| GSE43922 | Up | 0.3261954854 |
| GSE24585 | Down | -0.1218223747 |
| GSE37065 | Up | 0.0069790919 |
| GSE28863_A1 | Up | 0.0242927392 |
| GSE28863_A2 | Up | 0.1531786981 |
| GSE28863_A3 | Down | -0.3722379025 |
| GSE28863_A4 | Up | 0.0174852226 |
| GSE48662 | Up | 0.3367812384 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041517 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044813 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99a-5p | MIMAT0000097 | MIRT048691 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048862 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26474459 | Protease-activated receptor-1 (PAR-1) recently emerged as a critical component in the context of fibrotic lung diseases |
| 26474459 | The number of macrophages were significantly reduced in lungs of PAR-1 antagonist (P1pal-12) treated animals upon bleomycin instillation |
| 26474459 | In line with these data, PAR-1 stimulation increased monocyte / macrophage recruitment in response to epithelium injury in in vitro trans-well assays |
| 26474459 | Interestingly, these profibrotic effects were partially inhibited by treatment with the PAR-1 inhibitor P1pal-12 |
| 26474459 | Finally, we show that the macrophage-dependent induction of PAR-1 driven TGF-beta activation was mediated by FXa |
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