HCSGD entry for FLCN

1. General information

Official gene symbolFLCN
Entrez ID201163
Gene full namefolliculin
Other gene symbolsBHD FLCL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0001701In utero embryonic developmentISSbiological_process
GO:0001932Regulation of protein phosphorylationIDAbiological_process
GO:0001934Positive regulation of protein phosphorylationISSbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0007043Cell-cell junction assemblyISSbiological_process
GO:0010628Positive regulation of gene expressionISSbiological_process
GO:0010629Negative regulation of gene expressionISSbiological_process
GO:0010823Negative regulation of mitochondrion organizationISSbiological_process
GO:0030097HemopoiesisISSbiological_process
GO:0030308Negative regulation of cell growthIDAbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0030496MidbodyIDAcellular_component
GO:0030511Positive regulation of transforming growth factor beta receptor signaling pathwayIDA ISSbiological_process
GO:0031929TOR signalingIMPbiological_process
GO:0032006Regulation of TOR signalingISSbiological_process
GO:0032007Negative regulation of TOR signalingISSbiological_process
GO:0032008Positive regulation of TOR signalingISSbiological_process
GO:0032403Protein complex bindingIDAmolecular_function
GO:0032465Regulation of cytokinesisIMPbiological_process
GO:0035024Negative regulation of Rho protein signal transductionIMPbiological_process
GO:0035065Regulation of histone acetylationISSbiological_process
GO:0043065Positive regulation of apoptotic processISSbiological_process
GO:0044291Cell-cell contact zoneIDAcellular_component
GO:0045785Positive regulation of cell adhesionIMPbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMPbiological_process
GO:0051898Negative regulation of protein kinase B signalingISSbiological_process
GO:0070373Negative regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:1900181Negative regulation of protein localization to nucleusIDAbiological_process
GO:1901723Negative regulation of cell proliferation involved in kidney developmentISSbiological_process
GO:2000506Negative regulation of energy homeostasisISSbiological_process
GO:2000973Regulation of pro-B cell differentiationISSbiological_process
GO:2001170Negative regulation of ATP biosynthetic processISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.06633392730.99090369670.55484434561.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2747274606
GSE13712_SHEARUp0.4845749967
GSE13712_STATICUp0.1081200243
GSE19018Down-0.0588999172
GSE19899_A1Up0.1948680610
GSE19899_A2Up0.2231414264
PubMed_21979375_A1Down-0.0496380512
PubMed_21979375_A2Up0.3547476053
GSE35957Down-0.0675428000
GSE36640Up0.1037811813
GSE54402Up0.2189182653
GSE9593Up0.1664033376
GSE43922Up0.2080868746
GSE24585Up0.4909849209
GSE37065Up0.1254992995
GSE28863_A1Down-0.0063017071
GSE28863_A2Up0.2040571467
GSE28863_A3Up0.0664890455
GSE28863_A4Up0.1032783627
GSE48662Up0.0678077770

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-103a-3pMIMAT0000101MIRT026994SequencingFunctional MTI (Weak)20371350
hsa-miR-16-5pMIMAT0000069MIRT031444SequencingFunctional MTI (Weak)20371350
hsa-miR-615-3pMIMAT0003283MIRT040311CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.